Component
Alcoholic brain damage
Alcoholic brain damage. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The pathophysiology of alcoholic brain damage involves synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/7596324.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30469341e3044e901ef2ebfa2e84bfb83b48044a455f1f0e415662eb2a9c6368", "start_char": 0, "end_char": 1186, "text_sha256": "30469341e3044e901ef2ebfa2e84bfb83b48044a455f1f0e415662eb2a9c6368"}
- experimental_model
- Review of alcoholic brain damage separating ethanol, thiamine deficiency and liver disease
- exposure
- Chronic alcohol exposure with and without thiamine deficiency
- limitations
- A review, labelled as such. Its value here is that it insists the three causes be separated rather than merged into one syndrome.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human and animal
- plain_language
- The drinking and the missing vitamin do more damage together than either does alone.
- primary_references
- [alcohol-p7596324] Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. (1995). https://pubmed.ncbi.nlm.nih.gov/7596324/ DOI: 10.1007/bf01991777
- tissue_or_cell_type
- Brain
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 722–733
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Review of alcoholic brain damage separating ethanol, thiamine deficiency and liver disease · source_derived_draft · unverified_draft
### alcohol-thiamine-synergy The pathophysiology of alcoholic brain damage involves synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The drinking and the missing vitamin do more damage together than either does alone. organism: Human and animal tissue_or_cell_type: Brain experimental_model: Review of alcoholic brain damage separating ethanol, thiamine deficiency and liver disease limitations: A review, labelled as such. Its value here is that it insists the three causes be separated rather than merged into one syndrome. exposure: Chronic alcohol exposure with and without thiamine deficiency evidence_span: {"source_cache": "artifacts/alcohol-research/7596324.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "30469341e3044e901ef2ebfa2e84bfb83b48044a455f1f0e415662eb2a9c6368", "start_char": 0, "end_char": 1186, "text_sha256": "30469341e3044e901ef2ebfa2e84bfb83b48044a455f1f0e415662eb2a9c6368"} [alcohol-p7596324] Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. (1995). https://pubmed.ncbi.nlm.nih.gov/7596324/ DOI: 10.1007/bf01991777
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.