Component
Human mitochondrial m-AAA protease AFG3L2
Human mitochondrial m-AAA protease AFG3L2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
AFG3L2 mediated SLC25A39 degradation through matrix loop 1.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/38157846.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71", "start_char": 0, "end_char": 1145, "text_sha256": "8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71"}
- experimental_model
- Protein-interaction proteomics, knockout and neuronal regulation
- exposure
- AFG3L2 deletion and iron-sulfur sensing experiments
- limitations
- Protein-turnover regulation; no quantitative intake requirement is inferred.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human carrier in mammalian systems
- plain_language
- The cell regulates carrier abundance by breaking down the protein.
- primary_references
- [glutathione-p38157846] Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (2024). https://pubmed.ncbi.nlm.nih.gov/38157846/ DOI: 10.1016/j.molcel.2023.12.008
- tissue_or_cell_type
- Mitochondrial matrix-facing loop
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 541–552
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Protein-interaction proteomics, knockout and neuronal regulation · source_derived_draft · unverified_draft
### glutathione-afg3l2-a39 AFG3L2 mediated SLC25A39 degradation through matrix loop 1. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell regulates carrier abundance by breaking down the protein. organism: Human carrier in mammalian systems tissue_or_cell_type: Mitochondrial matrix-facing loop experimental_model: Protein-interaction proteomics, knockout and neuronal regulation limitations: Protein-turnover regulation; no quantitative intake requirement is inferred. exposure: AFG3L2 deletion and iron-sulfur sensing experiments evidence_span: {"source_cache": "artifacts/glutathione-research/38157846.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71", "start_char": 0, "end_char": 1145, "text_sha256": "8910cd64daf32714af4c954a4781163c2c5be3270e58eba14f7ff481e8a2cc71"} [glutathione-p38157846] Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (2024). https://pubmed.ncbi.nlm.nih.gov/38157846/ DOI: 10.1016/j.molcel.2023.12.008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.