Component
Advanced colorectal lesion incidence
Independently recorded substance, clinical endpoint or assay readout. Claims retain study-specific population and measurement context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Among 607 participants with a second follow-up, advanced lesions occurred in 11.6% versus 6.9% (RR 1.67; 95% CI 1.00–2.80; P=0.05).
Experimental context and source evidence
- experimental_model
- Randomized double-blind factorial trial in 1021 adults with recent colorectal adenomas; independently randomized aspirin exposure.
- exposure
- Folic acid 1 mg/day versus placebo; colonoscopy at first three-year interval and a later surveillance interval.
- limitations
- Secondary endpoint with substantial follow-up attrition and uncertainty; cannot establish that food folate causes cancer or identify the cellular mechanism.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- The later follow-up raised a possible adverse signal that must remain visible.
- primary_references
- [fol-cole2007] Folic acid for the prevention of colorectal adenomas: a randomized clinical trial (2007). https://pubmed.ncbi.nlm.nih.gov/17551129/ DOI: 10.1001/jama.297.21.2351
- tissue_or_cell_type
- Human blood or whole-person clinical endpoints
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1666–1676
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind factorial trial in 1021 adults with recent colorectal adenomas; independently randomized aspirin exposure. · source_derived_draft · unverified_draft
### fol-advanced-lesion-later-signal Among 607 participants with a second follow-up, advanced lesions occurred in 11.6% versus 6.9% (RR 1.67; 95% CI 1.00–2.80; P=0.05). Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The later follow-up raised a possible adverse signal that must remain visible. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person clinical endpoints experimental_model: Randomized double-blind factorial trial in 1021 adults with recent colorectal adenomas; independently randomized aspirin exposure. limitations: Secondary endpoint with substantial follow-up attrition and uncertainty; cannot establish that food folate causes cancer or identify the cellular mechanism. exposure: Folic acid 1 mg/day versus placebo; colonoscopy at first three-year interval and a later surveillance interval. [fol-cole2007] Folic acid for the prevention of colorectal adenomas: a randomized clinical trial (2007). https://pubmed.ncbi.nlm.nih.gov/17551129/ DOI: 10.1001/jama.297.21.2351
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.