Component
Acycloretinal
Acycloretinal. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Purified recombinant human BCO1 generated acycloretinal from lycopene, with reported catalytic efficiency similar to beta-carotene.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/24187135.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf8ce69a4772c58e274590a2e3f251bed46de77b4d844b54c98d39fcd27e3e91", "start_char": 0, "end_char": 1772, "text_sha256": "cf8ce69a4772c58e274590a2e3f251bed46de77b4d844b54c98d39fcd27e3e91"}
- experimental_model
- Purified recombinant human enzyme kinetics
- exposure
- Substrate panel; product chromatography
- limitations
- Activity in a purified enzyme system does not establish dominant in-vivo flux; acycloretinal is not retinal or vitamin A.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human BCO1 expressed in E. coli
- plain_language
- This product lacks the ring of vitamin-A retinal; cleavage does not make lycopene a vitamin A source.
- primary_references
- [lycopene-p24187135] Substrate specificity of purified recombinant human β-carotene 15,15'-oxygenase (BCO1). (2013). https://pubmed.ncbi.nlm.nih.gov/24187135/ DOI: 10.1074/jbc.m113.507160
- tissue_or_cell_type
- Cell-free carotenoid cleavage
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 377–388
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified recombinant human enzyme kinetics · source_derived_draft · unverified_draft
### lycopene-bco1-acycloretinal Purified recombinant human BCO1 generated acycloretinal from lycopene, with reported catalytic efficiency similar to beta-carotene. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: This product lacks the ring of vitamin-A retinal; cleavage does not make lycopene a vitamin A source. organism: Human BCO1 expressed in E. coli tissue_or_cell_type: Cell-free carotenoid cleavage experimental_model: Purified recombinant human enzyme kinetics limitations: Activity in a purified enzyme system does not establish dominant in-vivo flux; acycloretinal is not retinal or vitamin A. exposure: Substrate panel; product chromatography evidence_span: {"source_cache": "artifacts/lycopene-research/24187135.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf8ce69a4772c58e274590a2e3f251bed46de77b4d844b54c98d39fcd27e3e91", "start_char": 0, "end_char": 1772, "text_sha256": "cf8ce69a4772c58e274590a2e3f251bed46de77b4d844b54c98d39fcd27e3e91"} [lycopene-p24187135] Substrate specificity of purified recombinant human β-carotene 15,15'-oxygenase (BCO1). (2013). https://pubmed.ncbi.nlm.nih.gov/24187135/ DOI: 10.1074/jbc.m113.507160
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.