Component
Acidity below pH 5
The condition under which the standardised product loses nattokinase activity in stability testing. Fasting gastric pH sits well below it, which is why this is recorded as a step rather than as a caveat, but no study read here measured the enzyme in a stomach.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In product testing at 25 C, NSK-SD retained activity for 24 h between pH 5.5 and 10 but was labile below pH 5.0.
Experimental context and source evidence
- duration
- 24 h
- evidence_access
- EFSA Journal opinion retrieved and read in full during this curation. Quoted figures are from the opinion text and its specification tables.
- experimental_model
- Product stability testing
- exposure
- NSK-SD
- limitations
- A product stability measurement, not a human gastric-survival measurement: fasting gastric pH is well below 5.0. An applicant assay of the softgel at pH 2.0 mimicking gastric fluid was submitted to EFSA, but the opinion records only that the results were provided, not what they were.
- organism
- Product stability testing
- plain_language
- In product testing at 25 C, NSK-SD retained activity for 24 h between pH 5.5 and 10 but was labile below pH 5.0.
- primary_references
- Safety of fermented soybean extract NSK-SD as a novel food. (2016) DOI: 10.2903/j.efsa.2016.4541 Not indexed in PubMed.
- route
- In vitro
- tissue
- 25% aqueous product solution at 25 C
Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23) · lines 1368–1368
Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text. · supports · Product stability testing · source_derived_draft · unverified_draft
In product testing at 25 C, NSK-SD retained activity for 24 h between pH 5.5 and 10 but was labile below pH 5.0.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.