Component
Nonfunctional ABCA1 in Tangier disease fibroblasts
Human fibroblast ABCA1 machinery impairment; precise patient alleles are not assigned here.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
ApoA-I failed to remove alpha-tocopherol from Tangier disease fibroblasts with nonfunctional ABCA1.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Normal versus Tangier disease fibroblasts
- exposure
- Radiolabeled alpha-tocopherol; cholesterol/8-bromo-cAMP pretreatment; 6-hour apoA-I efflux assay.
- limitations
- Patient-cell machinery defect; not dietary deprivation or a claim that all HDL-mediated efflux is absent.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- An inherited transporter defect blocked this vitamin E export route in patient cells.
- primary_references
- [oram2001] ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. (2001). https://pubmed.ncbi.nlm.nih.gov/11546785/ DOI: 10.1074/jbc.m106984200
- tissue_or_cell_type
- Cultured fibroblasts
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 285–296
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Normal versus Tangier disease fibroblasts · source_derived_draft · unverified_draft
### ve-transport-abca1-tangier-efflux-loss ApoA-I failed to remove alpha-tocopherol from Tangier disease fibroblasts with nonfunctional ABCA1. Condition category: machinery_impairment nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: An inherited transporter defect blocked this vitamin E export route in patient cells. organism: Homo sapiens tissue_or_cell_type: Cultured fibroblasts experimental_model: Normal versus Tangier disease fibroblasts limitations: Patient-cell machinery defect; not dietary deprivation or a claim that all HDL-mediated efflux is absent. exposure: Radiolabeled alpha-tocopherol; cholesterol/8-bromo-cAMP pretreatment; 6-hour apoA-I efflux assay. cross_nutrient: false [oram2001] ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. (2001). https://pubmed.ncbi.nlm.nih.gov/11546785/ DOI: 10.1074/jbc.m106984200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.