Component
8-Gingerol plasma glucuronides, attachment position unresolved
Conjugate pool inferred from enzymatic hydrolysis in human plasma; not assigned to a specific positional glucuronide.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After oral ginger, plasma 8-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 8-gingerol was not detected in this study.
Experimental context and source evidence
- dose
- Single ginger-product dose 100 mg to 2 g
- duration
- Blood sampling 15 min to 72 h
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- 27 healthy human volunteers
- limitations
- Conjugates assessed after hydrolysis; measured total/conjugated exposure is not free parent concentration or tissue target engagement.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- 27 healthy human volunteers
- plain_language
- After oral ginger, plasma 8-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 8-gingerol was not detected in this study.
- primary_references
- Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18708382/ DOI: 10.1158/1055-9965.EPI-07-2934
- route
- Oral mixed ginger product
- tissue
- Plasma
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 360–369
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · 27 healthy human volunteers · source_derived_draft · unverified_draft
## gingerols-8-human-glucuronides After oral ginger, plasma 8-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 8-gingerol was not detected in this study. Model/species: 27 healthy human volunteers Tissue: Plasma Exposure: Single ginger-product dose 100 mg to 2 g Route: Oral mixed ginger product Duration: Blood sampling 15 min to 72 h Limits: Conjugates assessed after hydrolysis; measured total/conjugated exposure is not free parent concentration or tissue target engagement. Primary reference: Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18708382/ DOI: 10.1158/1055-9965.EPI-07-2934 Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.