Component
5-Nitro-gamma-tocopherol
Gamma-tocopherol nitration product with the nitro substituent at chromanol position 5.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SIN-1 exposure converted gamma-tocopherol to 5-nitro-gamma-tocopherol in soybean phosphatidylcholine liposomes and isolated human LDL. Product yields were approximately 50% and 75%, respectively; alpha-tocopherol did not prevent gamma nitration.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- HPLC analysis of tocopherols and nitration products
- exposure
- Liposomes: 20 mM phosphatidylcholine, 20 µM tocopherol and 1 mM SIN-1 at 37°C. LDL: 0.2 mM SIN-1; Figure 3 initial gamma-tocopherol 0.98 µM.
- limitations
- This identifies a stable nitration product, not every reactive intermediate or clinical anti-inflammatory efficacy. Liposome-versus-LDL antioxidant rankings differed.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Cell-free and Homo sapiens-derived LDL
- plain_language
- Gamma-tocopherol captured nitrating chemistry as a measurable nitrogen-containing product in artificial membranes and isolated blood lipoproteins.
- primary_references
- [christen1997] gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. (1997). https://pubmed.ncbi.nlm.nih.gov/9096373/ DOI: 10.1073/pnas.94.7.3217
- tissue_or_cell_type
- Soybean phosphatidylcholine liposomes; isolated plasma LDL
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 816–827
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC analysis of tocopherols and nitration products · source_derived_draft · unverified_draft
### e-sig-gamma-nitro-product SIN-1 exposure converted gamma-tocopherol to 5-nitro-gamma-tocopherol in soybean phosphatidylcholine liposomes and isolated human LDL. Product yields were approximately 50% and 75%, respectively; alpha-tocopherol did not prevent gamma nitration. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Gamma-tocopherol captured nitrating chemistry as a measurable nitrogen-containing product in artificial membranes and isolated blood lipoproteins. organism: Cell-free and Homo sapiens-derived LDL tissue_or_cell_type: Soybean phosphatidylcholine liposomes; isolated plasma LDL experimental_model: HPLC analysis of tocopherols and nitration products limitations: This identifies a stable nitration product, not every reactive intermediate or clinical anti-inflammatory efficacy. Liposome-versus-LDL antioxidant rankings differed. exposure: Liposomes: 20 mM phosphatidylcholine, 20 µM tocopherol and 1 mM SIN-1 at 37°C. LDL: 0.2 mM SIN-1; Figure 3 initial gamma-tocopherol 0.98 µM. cross_nutrient: false [christen1997] gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. (1997). https://pubmed.ncbi.nlm.nih.gov/9096373/ DOI: 10.1073/pnas.94.7.3217
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.