Component
4-Hydroxybenzoate
4-Hydroxybenzoate. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
A homozygous COQ2 variant caused severe impairment of CoQ10 synthesis in patient fibroblasts.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/coq10-research/16400613.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bd16a213ac563cf32b275cdee32ba3082e6c296cf9129e0930e2f96f0d2dc72a", "start_char": 0, "end_char": 1000, "text_sha256": "bd16a213ac563cf32b275cdee32ba3082e6c296cf9129e0930e2f96f0d2dc72a"}
- experimental_model
- Family sequencing and fibroblast tracer assays
- exposure
- Homozygous COQ2 missense variant
- limitations
- Rare primary deficiency; sequence numbering follows the original publication.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Human siblings
- plain_language
- Having the building blocks does not help if the enzyme that joins them is defective.
- primary_references
- [coq10-p16400613] A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/16400613/ DOI: 10.1086/500092
- tissue_or_cell_type
- CoQ synthesis
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 229–240
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Family sequencing and fibroblast tracer assays · source_derived_draft · unverified_draft
### coq10-coq2-loss A homozygous COQ2 variant caused severe impairment of CoQ10 synthesis in patient fibroblasts. Condition category: machinery_impairment nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Having the building blocks does not help if the enzyme that joins them is defective. organism: Human siblings tissue_or_cell_type: CoQ synthesis experimental_model: Family sequencing and fibroblast tracer assays limitations: Rare primary deficiency; sequence numbering follows the original publication. exposure: Homozygous COQ2 missense variant evidence_span: {"source_cache": "artifacts/coq10-research/16400613.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bd16a213ac563cf32b275cdee32ba3082e6c296cf9129e0930e2f96f0d2dc72a", "start_char": 0, "end_char": 1000, "text_sha256": "bd16a213ac563cf32b275cdee32ba3082e6c296cf9129e0930e2f96f0d2dc72a"} [coq10-p16400613] A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/16400613/ DOI: 10.1086/500092
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.