Component

4-Deoxypyridoxine

Desoxypyridoxine, the experimental B6 antagonist used in the historical combined-depletion study.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. The five men receiving B5/B6-deficient diet plus both antagonists failed to respond to tetanus and typhoid O immunization and had little typhoid H response.

    Pantothenate (vitamin B5) → Antibody response to tetanus and typhoid immunization source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved.
    experimental_model
    Historical two-stage combined B5/B6 depletion experiment in male volunteers
    exposure
    First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary.
    limitations
    Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Combined depletion and antivitamins impaired some antibody responses.
    primary_references
    [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    tissue_or_cell_type
    Immunization responses and serum proteins
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1327–1339

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical two-stage combined B5/B6 depletion experiment in male volunteers · source_derived_draft · unverified_draft

    ### b5-clin-combined-antibody-loss The five men receiving B5/B6-deficient diet plus both antagonists failed to respond to tetanus and typhoid O immunization and had little typhoid H response. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Combined depletion and antivitamins impaired some antibody responses. organism: Homo sapiens tissue_or_cell_type: Immunization responses and serum proteins experimental_model: Historical two-stage combined B5/B6 depletion experiment in male volunteers limitations: Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure. exposure: First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary. cross_nutrient: true evidence_location: Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved. [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    Complete structured claim and evidence

  2. After vitamins were restored and the five subjects were reimmunized, tetanus and typhoid antibody responses were reported as normal.

    Pantothenate (vitamin B5) → Antibody response to tetanus and typhoid immunization source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved.
    experimental_model
    Historical two-stage combined B5/B6 depletion experiment in male volunteers
    exposure
    First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary.
    limitations
    Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure. This is not a blinded comparison of B5 alone, B6 alone or their interaction.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Responses recovered after combined vitamin restoration and another immunization.
    primary_references
    [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    tissue_or_cell_type
    Immunization responses and serum proteins
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1355–1367

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical two-stage combined B5/B6 depletion experiment in male volunteers · source_derived_draft · unverified_draft

    ### b5-clin-combined-immune-recovery After vitamins were restored and the five subjects were reimmunized, tetanus and typhoid antibody responses were reported as normal. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Responses recovered after combined vitamin restoration and another immunization. organism: Homo sapiens tissue_or_cell_type: Immunization responses and serum proteins experimental_model: Historical two-stage combined B5/B6 depletion experiment in male volunteers limitations: Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure. This is not a blinded comparison of B5 alone, B6 alone or their interaction. exposure: First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary. cross_nutrient: true evidence_location: Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved. [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    Complete structured claim and evidence

  3. The same five men retained strong antibody responses to polio immunization despite their impaired tetanus and typhoid responses.

    Pantothenate (vitamin B5) → Antibody response to polio immunization source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    true
    evidence_location
    Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved.
    experimental_model
    Historical two-stage combined B5/B6 depletion experiment in male volunteers
    exposure
    First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary.
    limitations
    Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    The immune impairment did not affect every tested antigen equally.
    primary_references
    [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    tissue_or_cell_type
    Immunization responses and serum proteins
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1341–1353

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical two-stage combined B5/B6 depletion experiment in male volunteers · source_derived_draft · unverified_draft

    ### b5-clin-combined-polio-preserved The same five men retained strong antibody responses to polio immunization despite their impaired tetanus and typhoid responses. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: The immune impairment did not affect every tested antigen equally. organism: Homo sapiens tissue_or_cell_type: Immunization responses and serum proteins experimental_model: Historical two-stage combined B5/B6 depletion experiment in male volunteers limitations: Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure. exposure: First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary. cross_nutrient: true evidence_location: Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved. [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards