{"id":"7df70140-3b9f-5d14-a3c4-bd63329c7cfe","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-combined-antibody-loss","predicate":"combined-restriction-impairs","statement":"The five men receiving B5/B6-deficient diet plus both antagonists failed to respond to tetanus and typhoid O immunization and had little typhoid H response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"52b6a323-bb0f-5477-b3c3-87d12faa8a51","mechanism_event_label":"Combined depletion and antivitamins impaired some antibody responses.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"82521c43-9173-53db-b3b7-157a96deff4a","slug":"tetanus-typhoid-antibody-response","display_name":"Antibody response to tetanus and typhoid immunization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"52b6a323-bb0f-5477-b3c3-87d12faa8a51","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-combined-antibody-loss-event","event_type":"observed_intervention","label":"Combined depletion and antivitamins impaired some antibody responses.","description":"The five men receiving B5/B6-deficient diet plus both antagonists failed to respond to tetanus and typhoid O immunization and had little typhoid H response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"co-restricted vitamin","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e3aec528-bdfb-54a8-9b32-53fd3f1b9ff9","slug":"omega-methyl-pantothenate","display_name":"Omega-methyl pantothenic acid","entity_type_key":"small_molecule"},"role":"B5 antagonist","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"71d53291-26f5-5204-8956-a144a475e995","slug":"4-deoxypyridoxine","display_name":"4-Deoxypyridoxine","entity_type_key":"small_molecule"},"role":"B6 antagonist","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"82521c43-9173-53db-b3b7-157a96deff4a","slug":"tetanus-typhoid-antibody-response","display_name":"Antibody response to tetanus and typhoid immunization","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical two-stage combined B5/B6 depletion experiment in male volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Combined depletion and antivitamins impaired some antibody responses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Immunization responses and serum proteins","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1134955e-386d-54c3-8b77-ed7796e42197","evidence_kind":"source_excerpt","locator":"Lines 1327-1339","start_line":1327,"end_line":1339,"excerpt":"### b5-clin-combined-antibody-loss\nThe five men receiving B5/B6-deficient diet plus both antagonists failed to respond to tetanus and typhoid O immunization and had little typhoid H response.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Combined depletion and antivitamins impaired some antibody responses.\norganism: Homo sapiens\ntissue_or_cell_type: Immunization responses and serum proteins\nexperimental_model: Historical two-stage combined B5/B6 depletion experiment in male volunteers\nlimitations: Combined nutrient restriction plus antivitamins cannot identify the separate contribution of B5 or B6, a synergistic effect, or a universal immune defect. Reimmunization also changes prior antigen exposure.\nexposure: First stage: two controls, two diet-only deficient men and one receiving diet plus both antagonists. Second stage: five men received B5/B6-deficient diet plus omega-methyl pantothenic acid and desoxypyridoxine; exact doses not available in the publisher summary.\ncross_nutrient: true\nevidence_location: Publisher primary Summary at https://www.sciencedirect.com/science/article/abs/pii/S0002916523345945 ; full article not retrieved.\n[b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187","model_system":"Historical two-stage combined B5/B6 depletion experiment in male volunteers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-hodges1962] Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. (1962). https://pubmed.ncbi.nlm.nih.gov/13907960/ DOI: 10.1093/ajcn/11.3.187","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}