Component

3-prime-Dehydrolutein

3-prime-Dehydrolutein. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Dose-normalized bioavailability was 40% lower at 10 mg than at 1 mg.

    Dietary (3R,3-prime-R)-zeaxanthin → Human plasma zeaxanthin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"}
    experimental_model
    Repeated-dose plasma kinetic study
    exposure
    1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76
    limitations
    Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses.
    nutrient_topic
    Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
    organism
    20 healthy volunteers
    plain_language
    Ten times the dose did not give ten times the normalized response.
    primary_references
    [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    tissue_or_cell_type
    Plasma

    Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 860–871

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Repeated-dose plasma kinetic study · source_derived_draft · unverified_draft

    ### zeaxanthin-dose-normalized Dose-normalized bioavailability was 40% lower at 10 mg than at 1 mg. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Ten times the dose did not give ten times the normalized response. organism: 20 healthy volunteers tissue_or_cell_type: Plasma experimental_model: Repeated-dose plasma kinetic study limitations: Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses. exposure: 1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76 evidence_span: {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"} [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    Complete structured claim and evidence

  2. The 3-prime-dehydrolutein time course supported its formation from zeaxanthin, without identifying the responsible enzyme.

    Dietary (3R,3-prime-R)-zeaxanthin → Human plasma 3-prime-dehydrolutein concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"}
    experimental_model
    Repeated-dose plasma kinetic study
    exposure
    1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76
    limitations
    Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses.
    nutrient_topic
    Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
    organism
    20 healthy volunteers
    plain_language
    A circulating metabolite followed pigment intake.
    primary_references
    [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    tissue_or_cell_type
    Plasma

    Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 873–884

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Repeated-dose plasma kinetic study · source_derived_draft · unverified_draft

    ### zeaxanthin-metabolite-timecourse The 3-prime-dehydrolutein time course supported its formation from zeaxanthin, without identifying the responsible enzyme. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A circulating metabolite followed pigment intake. organism: 20 healthy volunteers tissue_or_cell_type: Plasma experimental_model: Repeated-dose plasma kinetic study limitations: Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses. exposure: 1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76 evidence_span: {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"} [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    Complete structured claim and evidence

  3. Daily 1 and 10 mg doses raised plasma zeaxanthin approximately four- and twentyfold, respectively.

    Dietary (3R,3-prime-R)-zeaxanthin → Human plasma zeaxanthin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"}
    experimental_model
    Repeated-dose plasma kinetic study
    exposure
    1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76
    limitations
    Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses.
    nutrient_topic
    Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
    organism
    20 healthy volunteers
    plain_language
    More intake raised blood levels, but not proportionally.
    primary_references
    [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    tissue_or_cell_type
    Plasma

    Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 847–858

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Repeated-dose plasma kinetic study · source_derived_draft · unverified_draft

    ### zeaxanthin-plasma-dose-response Daily 1 and 10 mg doses raised plasma zeaxanthin approximately four- and twentyfold, respectively. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: More intake raised blood levels, but not proportionally. organism: 20 healthy volunteers tissue_or_cell_type: Plasma experimental_model: Repeated-dose plasma kinetic study limitations: Plasma kinetics do not define retinal adequacy or a dose recommendation; metabolite origin is inferred from time courses. exposure: 1 or 10 mg synthetic zeaxanthin daily for 42 days; follow-up to day 76 evidence_span: {"source_cache": "artifacts/zeaxanthin-research/14985215.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88", "start_char": 0, "end_char": 1830, "text_sha256": "dfc182ac3b22c31acf68cf01ed05f57cfb325798513d570a4071e8c19fd39c88"} [zeaxanthin-p14985215] Plasma kinetics of zeaxanthin and 3'-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. (2004). https://pubmed.ncbi.nlm.nih.gov/14985215/ DOI: 10.1093/ajcn/79.3.410
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards