Component
24R,25-Dihydroxyvitamin D2
Initial C24R-hydroxylated product of human CYP24A1 acting on 25-hydroxyvitamin D2.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human CYP24A1 initiated 25-hydroxyvitamin D2 oxidation by hydroxylation at C24R in the vesicle-reconstituted enzyme system.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary abstract: identified C24R products and comparative initial-rate kinetics.
- experimental_model
- Partially purified human CYP24A1 product analysis
- exposure
- 25(OH)D2 substrate; concentration/time not specified in retrieved primary abstract.
- limitations
- Additional oxidation sites and products were not all fully identified; this is one identified initial route.
- nutrient
- Vitamin D2 and D3 · Vitamin D2 and D3
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens protein
- plain_language
- CYP24A1 begins one breakdown route for the D2 precursor.
- primary_references
- [li2023] Inactivation of vitamin D2 metabolites by human CYP24A1. (2023). https://pubmed.ncbi.nlm.nih.gov/37495192/ DOI: 10.1016/j.jsbmb.2023.106368
- tissue_or_cell_type
- phospholipid-vesicle membrane
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 512–525
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Partially purified human CYP24A1 product analysis · source_derived_draft · unverified_draft
### vd-act-cyp24a1-25d2 Human CYP24A1 initiated 25-hydroxyvitamin D2 oxidation by hydroxylation at C24R in the vesicle-reconstituted enzyme system. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: CYP24A1 begins one breakdown route for the D2 precursor. organism: Homo sapiens protein tissue_or_cell_type: phospholipid-vesicle membrane experimental_model: Partially purified human CYP24A1 product analysis limitations: Additional oxidation sites and products were not all fully identified; this is one identified initial route. exposure: 25(OH)D2 substrate; concentration/time not specified in retrieved primary abstract. cross_nutrient: false evidence_location: Primary abstract: identified C24R products and comparative initial-rate kinetics. nutrient: Vitamin D2 and D3 [li2023] Inactivation of vitamin D2 metabolites by human CYP24A1. (2023). https://pubmed.ncbi.nlm.nih.gov/37495192/ DOI: 10.1016/j.jsbmb.2023.106368
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.