Component
15-Deoxy-delta12,14-prostaglandin J2
Experimental species, exposure and limitations are retained on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Indicaxanthin pretreatment increased production of 15-deoxy-PGJ2 in LPS-stimulated RAW 264.7 cells.
Experimental context and source evidence
- dose
- Indicaxanthin 50-100 micromolar; LPS 1 microgram/mL
- duration
- Indicaxanthin 1 h before LPS; signaling time courses 0.5-16 h
- evidence_access
- Primary open full text, relevant results/methods and PubMed metadata.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Mouse RAW 264.7 macrophages
- limitations
- High cell-culture exposure; expression changes are not direct enzyme binding. Pro-oxidant signaling in this setting differs from red-cell antioxidant preservation.
- nutrient_topic
- Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved. · Indicaxanthin
- organism
- Mouse RAW 264.7 macrophages
- plain_language
- Indicaxanthin pretreatment increased production of 15-deoxy-PGJ2 in LPS-stimulated RAW 264.7 cells.
- primary_references
- Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages. (2014). https://pubmed.ncbi.nlm.nih.gov/25180166/ DOI: 10.1016/j.redox.2014.07.004
- route
- In vitro pretreatment then challenge
- tissue
- Cellular membranes and prostaglandin pathway
Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 151–160
Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text. · supports · Mouse RAW 264.7 macrophages · source_derived_draft · unverified_draft
## indicaxanthin-macrophage-pgj2 Indicaxanthin pretreatment increased production of 15-deoxy-PGJ2 in LPS-stimulated RAW 264.7 cells. Model/species: Mouse RAW 264.7 macrophages Tissue: Cellular membranes and prostaglandin pathway Exposure: Indicaxanthin 50-100 micromolar; LPS 1 microgram/mL Route: In vitro pretreatment then challenge Duration: Indicaxanthin 1 h before LPS; signaling time courses 0.5-16 h Limits: High cell-culture exposure; expression changes are not direct enzyme binding. Pro-oxidant signaling in this setting differs from red-cell antioxidant preservation. Primary reference: Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages. (2014). https://pubmed.ncbi.nlm.nih.gov/25180166/ DOI: 10.1016/j.redox.2014.07.004 Access: Primary open full text, relevant results/methods and PubMed metadata.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.