Component
Trehalose
Trehalose. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Steady-state pool sizes of glucose and metabolic intermediates including adenine nucleotides and end products revealed no differences between adult Haemonchus contortus resistant or susceptible to benzimidazoles, all three strains had similar levels of total lipid, protein and free amino acid and produced a similar sum total of end products, and although the mebendazole-resistant strain showed a diversion of carbon flow to the ethanol-producing pathway and greater cyanide-sensitive aerobic carbon dioxide output, the extent to which these metabolic differences may be related to benzimidazole resistance is not readily apparent.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/6427605.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4834a68834e7916938d61b08f8dc38fb00085c0b43761372c8ef883da0d8cbf8", "start_char": 0, "end_char": 1809, "text_sha256": "4834a68834e7916938d61b08f8dc38fb00085c0b43761372c8ef883da0d8cbf8"}
- experimental_model
- Biochemical comparison of susceptible, mebendazole-resistant and thiabendazole-resistant Haemonchus contortus in vitro
- exposure
- Steady-state metabolite pools, end products and labelled carbon dioxide over 30 to 60 minute and 18 hour incubations
- limitations
- A broad metabolic survey across matched resistant and susceptible strains. Its own authors state the relationship to resistance is not apparent.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Nematode
- plain_language
- Resistant and susceptible worms handle sugar much the same, so metabolism is not where resistance lives.
- primary_references
- [mbz-p6427605] Energy metabolism of adult Haemonchus contortus in vitro: a comparison of benzimidazole-susceptible and -resistant strains. (1984). https://pubmed.ncbi.nlm.nih.gov/6427605/ DOI: 10.1016/0166-6851(84)90031-8
- tissue_or_cell_type
- Whole adult worms
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical comparison of susceptible, mebendazole-resistant and thiabendazole-resistant Haemonchus contortus in vitro · source_derived_draft · unverified_draft
### mbz-metabolism-does-not-explain-resistance Steady-state pool sizes of glucose and metabolic intermediates including adenine nucleotides and end products revealed no differences between adult Haemonchus contortus resistant or susceptible to benzimidazoles, all three strains had similar levels of total lipid, protein and free amino acid and produced a similar sum total of end products, and although the mebendazole-resistant strain showed a diversion of carbon flow to the ethanol-producing pathway and greater cyanide-sensitive aerobic carbon dioxide output, the extent to which these metabolic differences may be related to benzimidazole resistance is not readily apparent. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Resistant and susceptible worms handle sugar much the same, so metabolism is not where resistance lives. organism: Nematode tissue_or_cell_type: Whole adult worms experimental_model: Biochemical comparison of susceptible, mebendazole-resistant and thiabendazole-resistant Haemonchus contortus in vitro limitations: A broad metabolic survey across matched resistant and susceptible strains. Its own authors state the relationship to resistance is not apparent. exposure: Steady-state metabolite pools, end products and labelled carbon dioxide over 30 to 60 minute and 18 hour incubations evidence_span: {"source_cache": "artifacts/mebendazole-research/6427605.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4834a68834e7916938d61b08f8dc38fb00085c0b43761372c8ef883da0d8cbf8", "start_char": 0, "end_char": 1809, "text_sha256": "4834a68834e7916938d61b08f8dc38fb00085c0b43761372c8ef883da0d8cbf8"} [mbz-p6427605] Energy metabolism of adult Haemonchus contortus in vitro: a comparison of benzimidazole-susceptible and -resistant strains. (1984). https://pubmed.ncbi.nlm.nih.gov/6427605/ DOI: 10.1016/0166-6851(84)90031-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.