Component
Tip60 histone acetyltransferase
Tip60 histone acetyltransferase. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Mutagenesis and RNA interference revealed that the putative monocarboxylic acid transporter Tarag was essential for enhancement of immunodeficiency pathway signalling by dietary acetate, and reduced expression of the histone acetyltransferase Tip60 decreased that signalling and blocked rescue by dietary acetate and by other sources of intracellular acetyl-CoA, while interference with histone deacetylation augmented transcription of ecdysone-regulated genes including pathway targets.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/acetate-research/34107298.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5644412d174b2512ecf9cedea282b022d647b1b8a82f693a8f389da991425a", "start_char": 0, "end_char": 1179, "text_sha256": "4e5644412d174b2512ecf9cedea282b022d647b1b8a82f693a8f389da991425a"}
- experimental_model
- Drosophila mutagenesis and RNA interference in enteroendocrine cells of the anterior midgut
- exposure
- Dietary acetate with disruption of a monocarboxylic acid transporter, of histone deacetylation, and of the Tip60 acetyltransferase
- limitations
- This is a fly study. The mammalian relevance is the authors’ statement that the Tip60-steroid hormone axis is conserved, not a mammalian measurement.
- nutrient_topic
- Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. · Acetic acid
- organism
- Drosophila
- plain_language
- Acetate has to be carried inside the cell and turned into a chromatin mark; it is not read at the cell surface.
- primary_references
- [acetate-p34107298] Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. (2021). https://pubmed.ncbi.nlm.nih.gov/34107298/ DOI: 10.1016/j.immuni.2021.05.017
- tissue_or_cell_type
- Anterior midgut
- transport_effect
- raises The transporter was required for dietary acetate to reach the intracellular acetyl-CoA route.
- transport_pool
- the intracellular acetate pool The transporter was required for dietary acetate to reach the intracellular acetyl-CoA route.
Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21) · lines 693–704
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Drosophila mutagenesis and RNA interference in enteroendocrine cells of the anterior midgut · source_derived_draft · unverified_draft
### acetate-acetate-must-enter Mutagenesis and RNA interference revealed that the putative monocarboxylic acid transporter Tarag was essential for enhancement of immunodeficiency pathway signalling by dietary acetate, and reduced expression of the histone acetyltransferase Tip60 decreased that signalling and blocked rescue by dietary acetate and by other sources of intracellular acetyl-CoA, while interference with histone deacetylation augmented transcription of ecdysone-regulated genes including pathway targets. Condition category: normal nutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. plain_language: Acetate has to be carried inside the cell and turned into a chromatin mark; it is not read at the cell surface. organism: Drosophila tissue_or_cell_type: Anterior midgut experimental_model: Drosophila mutagenesis and RNA interference in enteroendocrine cells of the anterior midgut limitations: This is a fly study. The mammalian relevance is the authors’ statement that the Tip60-steroid hormone axis is conserved, not a mammalian measurement. exposure: Dietary acetate with disruption of a monocarboxylic acid transporter, of histone deacetylation, and of the Tip60 acetyltransferase evidence_span: {"source_cache": "artifacts/acetate-research/34107298.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5644412d174b2512ecf9cedea282b022d647b1b8a82f693a8f389da991425a", "start_char": 0, "end_char": 1179, "text_sha256": "4e5644412d174b2512ecf9cedea282b022d647b1b8a82f693a8f389da991425a"} [acetate-p34107298] Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. (2021). https://pubmed.ncbi.nlm.nih.gov/34107298/ DOI: 10.1016/j.immuni.2021.05.017
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.