Component
2,3,7,8-Tetrachlorodibenzo-p-dioxin / TCDD
2,3,7,8-Tetrachlorodibenzo-p-dioxin / TCDD. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
DIM partly inhibited TCDD-induced CYP1A1 transcription and strongly reduced the induced EROD activity in T47D cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/8866829.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6df68a4c8fabdb1ec4bf4c05e25c0ac350fe1505222b1423cd2124e26c9eb7f", "start_char": 0, "end_char": 1403, "text_sha256": "b6df68a4c8fabdb1ec4bf4c05e25c0ac350fe1505222b1423cd2124e26c9eb7f"}
- experimental_model
- Receptor competition, reporter and enzyme assays
- exposure
- DIM alone up to 31 micromolar or with TCDD
- limitations
- Partial antagonism of a coadministered strong ligand is not absence of all AhR binding or a contradiction of induction in another cell type.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- Human T47D breast-cancer cells
- plain_language
- Binding the same receptor can produce a weaker signal and reduce another ligand response.
- primary_references
- [dim-p8866829] Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. (1996). https://pubmed.ncbi.nlm.nih.gov/8866829/ DOI: 10.1016/0006-2952(96)00060-3
- tissue_or_cell_type
- AhR-mediated CYP1A1 response
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 324–335
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor competition, reporter and enzyme assays · source_derived_draft · unverified_draft
### dim-ahr-partial-antagonism DIM partly inhibited TCDD-induced CYP1A1 transcription and strongly reduced the induced EROD activity in T47D cells. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Binding the same receptor can produce a weaker signal and reduce another ligand response. organism: Human T47D breast-cancer cells tissue_or_cell_type: AhR-mediated CYP1A1 response experimental_model: Receptor competition, reporter and enzyme assays limitations: Partial antagonism of a coadministered strong ligand is not absence of all AhR binding or a contradiction of induction in another cell type. exposure: DIM alone up to 31 micromolar or with TCDD evidence_span: {"source_cache": "artifacts/dim-research/8866829.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6df68a4c8fabdb1ec4bf4c05e25c0ac350fe1505222b1423cd2124e26c9eb7f", "start_char": 0, "end_char": 1403, "text_sha256": "b6df68a4c8fabdb1ec4bf4c05e25c0ac350fe1505222b1423cd2124e26c9eb7f"} [dim-p8866829] Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. (1996). https://pubmed.ncbi.nlm.nih.gov/8866829/ DOI: 10.1016/0006-2952(96)00060-3
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.