Component
Solid-state transformation of one crystal form into another
Solid-state transformation of one crystal form into another. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In an accelerated stability study, form C was converted to the thermodynamically stable and least soluble form A with increased temperature and moisture, the transformation was significantly increased at constant temperature and humidity when trace amounts of form A were already present, four of the seven products tested contained trace amounts of form A, in some tablets transformation was so quick that it reduced shelf life to less than one month, and tablet dissolution of those products was reduced to the extent that it did not comply with USP and FDA specifications.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/19691117.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6005cbf9afb4151467910164f873d0956382c3bcc10cac8514326385b32e32b1", "start_char": 0, "end_char": 1296, "text_sha256": "6005cbf9afb4151467910164f873d0956382c3bcc10cac8514326385b32e32b1"}
- experimental_model
- Accelerated stability study of mebendazole tablets under ICH storage conditions
- exposure
- Storage at 30 degrees with 65% relative humidity and at 40 degrees with 75% relative humidity
- limitations
- Solid-state kinetics on marketed products, modelled with the Johnson-Mehl-Avrami-Erofeyev-Kolmogorov equation. It measures dissolution rather than patient outcome.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Pharmaceutical product
- plain_language
- The working form of the drug turns into the useless form on the shelf, faster if a trace of the useless form is already there.
- primary_references
- [mbz-p19691117] Characterization of polymorph transformations that decrease the stability of tablets containing the WHO essential drug mebendazole. (2010). https://pubmed.ncbi.nlm.nih.gov/19691117/ DOI: 10.1002/jps.21899
- tissue_or_cell_type
- Tablets
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Accelerated stability study of mebendazole tablets under ICH storage conditions · source_derived_draft · unverified_draft
### mbz-crystal-form-sets-solubility In an accelerated stability study, form C was converted to the thermodynamically stable and least soluble form A with increased temperature and moisture, the transformation was significantly increased at constant temperature and humidity when trace amounts of form A were already present, four of the seven products tested contained trace amounts of form A, in some tablets transformation was so quick that it reduced shelf life to less than one month, and tablet dissolution of those products was reduced to the extent that it did not comply with USP and FDA specifications. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: The working form of the drug turns into the useless form on the shelf, faster if a trace of the useless form is already there. organism: Pharmaceutical product tissue_or_cell_type: Tablets experimental_model: Accelerated stability study of mebendazole tablets under ICH storage conditions limitations: Solid-state kinetics on marketed products, modelled with the Johnson-Mehl-Avrami-Erofeyev-Kolmogorov equation. It measures dissolution rather than patient outcome. exposure: Storage at 30 degrees with 65% relative humidity and at 40 degrees with 75% relative humidity evidence_span: {"source_cache": "artifacts/mebendazole-research/19691117.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6005cbf9afb4151467910164f873d0956382c3bcc10cac8514326385b32e32b1", "start_char": 0, "end_char": 1296, "text_sha256": "6005cbf9afb4151467910164f873d0956382c3bcc10cac8514326385b32e32b1"} [mbz-p19691117] Characterization of polymorph transformations that decrease the stability of tablets containing the WHO essential drug mebendazole. (2010). https://pubmed.ncbi.nlm.nih.gov/19691117/ DOI: 10.1002/jps.21899
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.