Component
Social interaction behaviour
Social interaction behaviour. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Cannabidiol pretreatment potentiated blood and brain THC levels with both acute and chronic administration in adolescent rats, potentiated the inhibition of body weight gain caused by chronic THC, and mildly augmented its anxiogenic, locomotor-suppressant and social-interaction effects.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/21667074.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "da582d1624586305da4993ae0e27e4d07352e46eda2ac97c88cc924f2a8ed598", "start_char": 0, "end_char": 1688, "text_sha256": "da582d1624586305da4993ae0e27e4d07352e46eda2ac97c88cc924f2a8ed598"}
- experimental_model
- Adolescent rats given ascending THC doses over 21 days with and without equivalent cannabidiol
- exposure
- Ascending THC 1 to 10 mg/kg over 21 days with cannabidiol pretreatment
- limitations
- A chronic animal study at equivalent doses, reaching the opposite conclusion to the human single-dose work on whether cannabidiol opposes THC.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Rat
- plain_language
- In young rats cannabidiol made THC stronger, not weaker.
- primary_references
- [thc-p21667074] Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. (2011). https://pubmed.ncbi.nlm.nih.gov/21667074/ DOI: 10.1007/s00213-011-2342-0
- tissue_or_cell_type
- Blood, brain and behaviour
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 569–580
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Adolescent rats given ascending THC doses over 21 days with and without equivalent cannabidiol · source_derived_draft · unverified_draft
### thc-cbd-potentiates-thc Cannabidiol pretreatment potentiated blood and brain THC levels with both acute and chronic administration in adolescent rats, potentiated the inhibition of body weight gain caused by chronic THC, and mildly augmented its anxiogenic, locomotor-suppressant and social-interaction effects. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: In young rats cannabidiol made THC stronger, not weaker. organism: Rat tissue_or_cell_type: Blood, brain and behaviour experimental_model: Adolescent rats given ascending THC doses over 21 days with and without equivalent cannabidiol limitations: A chronic animal study at equivalent doses, reaching the opposite conclusion to the human single-dose work on whether cannabidiol opposes THC. exposure: Ascending THC 1 to 10 mg/kg over 21 days with cannabidiol pretreatment evidence_span: {"source_cache": "artifacts/thc-research/21667074.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "da582d1624586305da4993ae0e27e4d07352e46eda2ac97c88cc924f2a8ed598", "start_char": 0, "end_char": 1688, "text_sha256": "da582d1624586305da4993ae0e27e4d07352e46eda2ac97c88cc924f2a8ed598"} [thc-p21667074] Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. (2011). https://pubmed.ncbi.nlm.nih.gov/21667074/ DOI: 10.1007/s00213-011-2342-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.