Component
Human serotonin transporter SERT / SLC6A4
Human serotonin transporter SERT / SLC6A4. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
SERT Asn101 experiments linked chloride binding to concentrative serotonin uptake.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/21730057.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef83bc710cfeb47a0815a2e11c431a5bb16a8927aa81eccc38b774c0dda454af", "start_char": 0, "end_char": 691, "text_sha256": "ef83bc710cfeb47a0815a2e11c431a5bb16a8927aa81eccc38b774c0dda454af"}
- experimental_model
- Mutagenesis, flux measurements and modeling
- exposure
- Asn101 substitutions and chloride-coupling assays
- limitations
- Transporter mechanism; no evidence that dietary chloride changes treat a mood disorder.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human SERT
- plain_language
- Chloride participates in neurotransmitter retrieval as well as in electrical signaling.
- primary_references
- [chloride-p21730057] A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. (2011). https://pubmed.ncbi.nlm.nih.gov/21730057/ DOI: 10.1074/jbc.m111.250308
- tissue_or_cell_type
- Expressed membrane transporter
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 445–456
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mutagenesis, flux measurements and modeling · source_derived_draft · unverified_draft
### chloride-sert-chloride-coupling SERT Asn101 experiments linked chloride binding to concentrative serotonin uptake. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Chloride participates in neurotransmitter retrieval as well as in electrical signaling. organism: Human SERT tissue_or_cell_type: Expressed membrane transporter experimental_model: Mutagenesis, flux measurements and modeling limitations: Transporter mechanism; no evidence that dietary chloride changes treat a mood disorder. exposure: Asn101 substitutions and chloride-coupling assays evidence_span: {"source_cache": "artifacts/chloride-research/21730057.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef83bc710cfeb47a0815a2e11c431a5bb16a8927aa81eccc38b774c0dda454af", "start_char": 0, "end_char": 691, "text_sha256": "ef83bc710cfeb47a0815a2e11c431a5bb16a8927aa81eccc38b774c0dda454af"} [chloride-p21730057] A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. (2011). https://pubmed.ncbi.nlm.nih.gov/21730057/ DOI: 10.1074/jbc.m111.250308
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.