Component
Human choline transporter-like protein 1 / SLC44A1
Human choline transporter-like protein 1 / SLC44A1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Patient fibroblasts had diminished choline transport.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/31855247.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34cbef18c0e83c0bcd06954a1d81d7329825171b5ecac31f8ea19b2457543f19", "start_char": 0, "end_char": 1785, "text_sha256": "34cbef18c0e83c0bcd06954a1d81d7329825171b5ecac31f8ea19b2457543f19"}
- experimental_model
- Four individuals, three families; patient-fibroblast transport and rescue
- exposure
- SLC44A1 frameshift genotypes, chronic choline treatment and acute iron challenge
- limitations
- Cell rescue is not a demonstrated clinical treatment. Preserved PC content coexisted with disturbed other lipids and organelles. The linked issue-wide erratum corrected publication year to 2020, not these biological findings (PMID 32333675; doi:10.1093/brain/awaa007).
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- Transport failed even though not every downstream concentration fell.
- primary_references
- [choline-p31855247] Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration. (2020). https://pubmed.ncbi.nlm.nih.gov/31855247/ DOI: 10.1093/brain/awz376
- tissue_or_cell_type
- Patient fibroblasts; clinical neurodegeneration
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 360–371
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Four individuals, three families; patient-fibroblast transport and rescue · source_derived_draft · unverified_draft
### choline-ctl1-uptake Patient fibroblasts had diminished choline transport. Condition category: machinery_impairment nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Transport failed even though not every downstream concentration fell. organism: Human tissue_or_cell_type: Patient fibroblasts; clinical neurodegeneration experimental_model: Four individuals, three families; patient-fibroblast transport and rescue limitations: Cell rescue is not a demonstrated clinical treatment. Preserved PC content coexisted with disturbed other lipids and organelles. The linked issue-wide erratum corrected publication year to 2020, not these biological findings (PMID 32333675; doi:10.1093/brain/awaa007). exposure: SLC44A1 frameshift genotypes, chronic choline treatment and acute iron challenge evidence_span: {"source_cache": "artifacts/choline-research/31855247.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "34cbef18c0e83c0bcd06954a1d81d7329825171b5ecac31f8ea19b2457543f19", "start_char": 0, "end_char": 1785, "text_sha256": "34cbef18c0e83c0bcd06954a1d81d7329825171b5ecac31f8ea19b2457543f19"} [choline-p31855247] Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration. (2020). https://pubmed.ncbi.nlm.nih.gov/31855247/ DOI: 10.1093/brain/awz376
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.