Component
Human ZIP14 (SLC39A14)
Human metal influx transporter; distinct from the mouse Slc39a14 ortholog.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
ZIP14 deletion in human Caco-2 Transwell cultures increased apical-to-basolateral manganese transport.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- ZIP14-deficient human Caco-2 Transwell monolayers
- exposure
- ZIP14-deficient versus control Caco-2 Transwell monolayers.
- limitations
- Directional flux in a transformed cell-line model is not a human fractional-absorption estimate.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Without ZIP14, the cultured intestinal barrier passed more manganese toward the blood-facing side.
- primary_references
- [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
- tissue_or_cell_type
- Caco-2 intestinal epithelial model
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 201–212
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ZIP14-deficient human Caco-2 Transwell monolayers · source_derived_draft · unverified_draft
### mn-trans-intestinal-zip14-absorptive ZIP14 deletion in human Caco-2 Transwell cultures increased apical-to-basolateral manganese transport. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Without ZIP14, the cultured intestinal barrier passed more manganese toward the blood-facing side. organism: Homo sapiens tissue_or_cell_type: Caco-2 intestinal epithelial model experimental_model: ZIP14-deficient human Caco-2 Transwell monolayers limitations: Directional flux in a transformed cell-line model is not a human fractional-absorption estimate. exposure: ZIP14-deficient versus control Caco-2 Transwell monolayers. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
Complete structured claim and evidenceZIP14 deletion in human Caco-2 Transwell cultures impaired basolateral-to-apical manganese transport.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- ZIP14-deficient human Caco-2 Transwell monolayers
- exposure
- ZIP14-deficient versus control Caco-2 Transwell monolayers.
- limitations
- Directional flux in a transformed cell-line model is not a human fractional-absorption estimate.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Intestinal ZIP14 supported movement of manganese toward the gut lumen.
- primary_references
- [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
- tissue_or_cell_type
- Caco-2 intestinal epithelial model
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 188–199
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ZIP14-deficient human Caco-2 Transwell monolayers · source_derived_draft · unverified_draft
### mn-trans-intestinal-zip14-secretory ZIP14 deletion in human Caco-2 Transwell cultures impaired basolateral-to-apical manganese transport. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Intestinal ZIP14 supported movement of manganese toward the gut lumen. organism: Homo sapiens tissue_or_cell_type: Caco-2 intestinal epithelial model experimental_model: ZIP14-deficient human Caco-2 Transwell monolayers limitations: Directional flux in a transformed cell-line model is not a human fractional-absorption estimate. exposure: ZIP14-deficient versus control Caco-2 Transwell monolayers. cross_nutrient: false [mn-trans-31028174] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. (2019). https://pubmed.ncbi.nlm.nih.gov/31028174/ DOI: 10.1074/jbc.ra119.008762
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.