Component
SC560, a cyclooxygenase-1 selective inhibitor
SC560, a cyclooxygenase-1 selective inhibitor. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Prostanoid production by rat aorta, heart, lung and whole blood was inhibited by all drugs tested with the order of potency SC560 greater than naproxen greater than acetaminophen greater than or equal to rofecoxib while in brain and cerebellum no differences among drug potencies were found, Western blotting using a commercially available antibody raised against canine COX-3 failed to detect any immunoreactive proteins, and the authors conclude that cyclooxygenase-1 and -2 are the functional forms present in the rat tissues tested, that acetaminophen is not a selective inhibitor of cyclooxygenase activities in the central nervous system, and that expression of an active cyclooxygenase protein from COX-3 messenger RNA in the rat is apparently impossible.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/paracetamol-research/15148345.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6ca43f39a9bb4cbc398f4f7f6e3401854f6c100b72fb7fdf952ee49486438d3c", "start_char": 0, "end_char": 1940, "text_sha256": "6ca43f39a9bb4cbc398f4f7f6e3401854f6c100b72fb7fdf952ee49486438d3c"}
- experimental_model
- Comparison of acetaminophen, rofecoxib, naproxen and SC560 across rat aorta, heart, lung, brain, cerebellum and whole blood
- exposure
- Four drugs of differing isoform selectivity, with transcript and protein detection including an anti-canine-COX-3 antibody
- limitations
- Tests the proposal functionally across tissues and looks for the protein directly. A rat study, and a negative Western blot is weaker evidence than a positive one.
- nutrient_topic
- Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. · Paracetamol
- organism
- Rat
- plain_language
- Nobody could find the protein, and in brain the drug showed no special selectivity at all.
- primary_references
- [apap-p15148345] Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues. (2004). https://pubmed.ncbi.nlm.nih.gov/15148345/ DOI: 10.1124/jpet.103.063875
- tissue_or_cell_type
- Multiple tissues
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Comparison of acetaminophen, rofecoxib, naproxen and SC560 across rat aorta, heart, lung, brain, cerebellum and whole blood · source_derived_draft · unverified_draft
### apap-no-cox3-protein-found Prostanoid production by rat aorta, heart, lung and whole blood was inhibited by all drugs tested with the order of potency SC560 greater than naproxen greater than acetaminophen greater than or equal to rofecoxib while in brain and cerebellum no differences among drug potencies were found, Western blotting using a commercially available antibody raised against canine COX-3 failed to detect any immunoreactive proteins, and the authors conclude that cyclooxygenase-1 and -2 are the functional forms present in the rat tissues tested, that acetaminophen is not a selective inhibitor of cyclooxygenase activities in the central nervous system, and that expression of an active cyclooxygenase protein from COX-3 messenger RNA in the rat is apparently impossible. Condition category: normal nutrient_topic: Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. plain_language: Nobody could find the protein, and in brain the drug showed no special selectivity at all. organism: Rat tissue_or_cell_type: Multiple tissues experimental_model: Comparison of acetaminophen, rofecoxib, naproxen and SC560 across rat aorta, heart, lung, brain, cerebellum and whole blood limitations: Tests the proposal functionally across tissues and looks for the protein directly. A rat study, and a negative Western blot is weaker evidence than a positive one. exposure: Four drugs of differing isoform selectivity, with transcript and protein detection including an anti-canine-COX-3 antibody evidence_span: {"source_cache": "artifacts/paracetamol-research/15148345.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6ca43f39a9bb4cbc398f4f7f6e3401854f6c100b72fb7fdf952ee49486438d3c", "start_char": 0, "end_char": 1940, "text_sha256": "6ca43f39a9bb4cbc398f4f7f6e3401854f6c100b72fb7fdf952ee49486438d3c"} [apap-p15148345] Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues. (2004). https://pubmed.ncbi.nlm.nih.gov/15148345/ DOI: 10.1124/jpet.103.063875
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.