Component
Salivary immunoglobulin A
Salivary immunoglobulin A. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The first study evaluated the effect of GABA intake by 13 subjects on their brain waves, with electroencephalograms obtained after three tests on each volunteer taking only water, GABA, or L-theanine, and after 60 minutes of administration GABA significantly increased alpha waves and decreased beta waves compared to water or L-theanine, while in a second study eight acrophobic subjects crossing a suspended bridge as a stressful stimulus showed a marked decrease of salivary immunoglobulin A in the placebo group while the GABA group showed significantly higher levels.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/16971751.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631", "start_char": 0, "end_char": 1322, "text_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631"}
- experimental_model
- Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor
- exposure
- Orally administered GABA against water and against L-theanine, and GABA against placebo in acrophobic subjects crossing a suspended bridge
- limitations
- Thirteen subjects in the first study and eight in the second, with no correction for multiple comparisons reported. The immunity claim rests on salivary immunoglobulin A in eight people.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Human
- plain_language
- A gram taken by mouth changed the pattern of brain waves within an hour in thirteen people.
- primary_references
- [gb-p16971751] Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. (2006). https://pubmed.ncbi.nlm.nih.gov/16971751/ DOI: 10.1002/biof.5520260305
- tissue_or_cell_type
- Brain electrical activity and saliva
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor · source_derived_draft · unverified_draft
### gb-oral-gaba-shifts-the-eeg The first study evaluated the effect of GABA intake by 13 subjects on their brain waves, with electroencephalograms obtained after three tests on each volunteer taking only water, GABA, or L-theanine, and after 60 minutes of administration GABA significantly increased alpha waves and decreased beta waves compared to water or L-theanine, while in a second study eight acrophobic subjects crossing a suspended bridge as a stressful stimulus showed a marked decrease of salivary immunoglobulin A in the placebo group while the GABA group showed significantly higher levels. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: A gram taken by mouth changed the pattern of brain waves within an hour in thirteen people. organism: Human tissue_or_cell_type: Brain electrical activity and saliva experimental_model: Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor limitations: Thirteen subjects in the first study and eight in the second, with no correction for multiple comparisons reported. The immunity claim rests on salivary immunoglobulin A in eight people. exposure: Orally administered GABA against water and against L-theanine, and GABA against placebo in acrophobic subjects crossing a suspended bridge evidence_span: {"source_cache": "artifacts/gaba-research/16971751.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631", "start_char": 0, "end_char": 1322, "text_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631"} [gb-p16971751] Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. (2006). https://pubmed.ncbi.nlm.nih.gov/16971751/ DOI: 10.1002/biof.5520260305
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.