Component
S-ibuprofenoyl-coenzyme A thioester
S-ibuprofenoyl-coenzyme A thioester. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Ibuprofen epimerization in humans is virtually irreversible from R to S, and 2-arylpropionyl-CoA epimerase readily converts R-ibuprofen-CoA into its S counterpart in active subcellular hepatic preparations, with examination of epimerase activity across tissues indicating that this metabolism occurs mainly in liver and kidney; reduced renal clearance together with metabolic bioactivation from inversion may raise plasma levels of the active species unpredictably.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ibuprofen-research/1680979.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4888135fd1db1817c370825ee8a1435b7654e68af33912093c725fe7041341cc", "start_char": 0, "end_char": 1119, "text_sha256": "4888135fd1db1817c370825ee8a1435b7654e68af33912093c725fe7041341cc"}
- experimental_model
- Enantioselective high performance liquid chromatography in humans with active subcellular hepatic preparations from rats
- exposure
- Racemic and single-enantiomer ibuprofen, with R-ibuprofen-CoA applied to subcellular fractions
- limitations
- Establishes the epimerase step directly on the thioester. The tissue survey is in rat; the human arm is the demonstration that inversion is one-way.
- nutrient_topic
- Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. · Ibuprofen
- organism
- Human and rat
- plain_language
- An enzyme flips the activated form from one hand to the other, mostly in the liver and kidney.
- primary_references
- [ibu-p1680979] Metabolic inversion of stereoisomeric ibuprofen in man. (1991). https://pubmed.ncbi.nlm.nih.gov/1680979/
- tissue_or_cell_type
- Liver and kidney
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Enantioselective high performance liquid chromatography in humans with active subcellular hepatic preparations from rats · source_derived_draft · unverified_draft
### ibu-epimerase-acts-on-the-thioester Ibuprofen epimerization in humans is virtually irreversible from R to S, and 2-arylpropionyl-CoA epimerase readily converts R-ibuprofen-CoA into its S counterpart in active subcellular hepatic preparations, with examination of epimerase activity across tissues indicating that this metabolism occurs mainly in liver and kidney; reduced renal clearance together with metabolic bioactivation from inversion may raise plasma levels of the active species unpredictably. Condition category: normal nutrient_topic: Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. plain_language: An enzyme flips the activated form from one hand to the other, mostly in the liver and kidney. organism: Human and rat tissue_or_cell_type: Liver and kidney experimental_model: Enantioselective high performance liquid chromatography in humans with active subcellular hepatic preparations from rats limitations: Establishes the epimerase step directly on the thioester. The tissue survey is in rat; the human arm is the demonstration that inversion is one-way. exposure: Racemic and single-enantiomer ibuprofen, with R-ibuprofen-CoA applied to subcellular fractions evidence_span: {"source_cache": "artifacts/ibuprofen-research/1680979.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4888135fd1db1817c370825ee8a1435b7654e68af33912093c725fe7041341cc", "start_char": 0, "end_char": 1119, "text_sha256": "4888135fd1db1817c370825ee8a1435b7654e68af33912093c725fe7041341cc"} [ibu-p1680979] Metabolic inversion of stereoisomeric ibuprofen in man. (1991). https://pubmed.ncbi.nlm.nih.gov/1680979/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.