Component
Catalytically inactive RDH10
Activity-impaired recombinant RDH10 construct used to distinguish catalytic and activating roles.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
RDH10 coexpression increased DHRS3 retinaldehyde reductase activity even when RDH10 itself was catalytically inactive.
Experimental context and source evidence
- evidence_location
- Abstract
- experimental_model
- Human RDH10/DHRS3 coexpression in HEK293 and Sf9 cells, plus Dhrs3-null embryos.
- exposure
- Coexpression including inactive RDH10 constructs.
- limitations
- Does not identify an exact complex stoichiometry or require substrate channeling.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens recombinant proteins
- outcome
- RDH10 coexpression increased DHRS3 retinaldehyde reductase activity even when RDH10 itself was catalytically inactive.
- plain_language
- The partner enzyme also acts through a noncatalytic interaction.
- primary_references
- [va-adams-2014] The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4031538/ DOI: 10.1074/jbc.M114.552257
- tissue_or_cell_type
- Sf9 microsomes and HEK293 cells
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 531–543
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human RDH10/DHRS3 coexpression in HEK293 and Sf9 cells, plus Dhrs3-null embryos. · source_derived_draft · unverified_draft
### va-rdh10-activates-dhrs3 RDH10 coexpression increased DHRS3 retinaldehyde reductase activity even when RDH10 itself was catalytically inactive. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: The partner enzyme also acts through a noncatalytic interaction. organism: Homo sapiens recombinant proteins tissue_or_cell_type: Sf9 microsomes and HEK293 cells experimental_model: Human RDH10/DHRS3 coexpression in HEK293 and Sf9 cells, plus Dhrs3-null embryos. limitations: Does not identify an exact complex stoichiometry or require substrate channeling. exposure: Coexpression including inactive RDH10 constructs. outcome: RDH10 coexpression increased DHRS3 retinaldehyde reductase activity even when RDH10 itself was catalytically inactive. evidence_location: Abstract [va-adams-2014] The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC4031538/ DOI: 10.1074/jbc.M114.552257
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.