Component
Rat liver microsomes
Rat liver microsomes. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
After two weeks of dihydrocapsaicin at 10 mg/kg/day the area under the plasma concentration-time curve for efavirenz increased from 8821 to 22347 micrograms per millilitre per hour, time to maximum plasma concentration increased from 2.50 to 3.50 hours and elimination half-life from 3.13 to 3.51 hours, while plasma clearance fell from 6.71 to 2.65 litres per hour per kilogram, and dihydrocapsaicin significantly inhibited the metabolism of efavirenz in rat liver microsomes; the authors conclude the dose should be monitored in patients on efavirenz maintenance therapy.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/41286578.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9063b8f1265e2ca00078e7452f81fc480eea4995c88a595cfbd42d245e74f68e", "start_char": 0, "end_char": 1538, "text_sha256": "9063b8f1265e2ca00078e7452f81fc480eea4995c88a595cfbd42d245e74f68e"}
- experimental_model
- Twelve Sprague-Dawley rats pretreated for two weeks, with rat liver microsome experiments
- exposure
- Dihydrocapsaicin 10 mg/kg/day for two weeks before a single oral 56 mg/kg dose of efavirenz
- limitations
- A named drug interaction with both in vivo and in vitro arms. Twelve rats in two groups, and a rat liver microsome system rather than a human one.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- Two weeks of the compound left two and a half times as much of an HIV drug in the blood.
- primary_references
- [dhc-p41286578] Impact of Dihydrocapsaicin on the Metabolism of Efavirenz In Vitro and In Vivo. (2025). https://pubmed.ncbi.nlm.nih.gov/41286578/ DOI: 10.1002/prp2.70189
- tissue_or_cell_type
- Liver and plasma
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve Sprague-Dawley rats pretreated for two weeks, with rat liver microsome experiments · source_derived_draft · unverified_draft
### dhc-efavirenz-interaction After two weeks of dihydrocapsaicin at 10 mg/kg/day the area under the plasma concentration-time curve for efavirenz increased from 8821 to 22347 micrograms per millilitre per hour, time to maximum plasma concentration increased from 2.50 to 3.50 hours and elimination half-life from 3.13 to 3.51 hours, while plasma clearance fell from 6.71 to 2.65 litres per hour per kilogram, and dihydrocapsaicin significantly inhibited the metabolism of efavirenz in rat liver microsomes; the authors conclude the dose should be monitored in patients on efavirenz maintenance therapy. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Two weeks of the compound left two and a half times as much of an HIV drug in the blood. organism: Rat tissue_or_cell_type: Liver and plasma experimental_model: Twelve Sprague-Dawley rats pretreated for two weeks, with rat liver microsome experiments limitations: A named drug interaction with both in vivo and in vitro arms. Twelve rats in two groups, and a rat liver microsome system rather than a human one. exposure: Dihydrocapsaicin 10 mg/kg/day for two weeks before a single oral 56 mg/kg dose of efavirenz evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/41286578.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9063b8f1265e2ca00078e7452f81fc480eea4995c88a595cfbd42d245e74f68e", "start_char": 0, "end_char": 1538, "text_sha256": "9063b8f1265e2ca00078e7452f81fc480eea4995c88a595cfbd42d245e74f68e"} [dhc-p41286578] Impact of Dihydrocapsaicin on the Metabolism of Efavirenz In Vitro and In Vivo. (2025). https://pubmed.ncbi.nlm.nih.gov/41286578/ DOI: 10.1002/prp2.70189
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.