Component
Osteoclast resorption lacuna
Biological or experimental compartment identified in the linked study.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Resorbing osteoclasts acidified the extracellular compartment beneath their ruffled border and reacidified it after ammonium chloride washout.
Experimental context and source evidence
- compartment_description
- Sealed extracellular resorption lacuna
- experimental_model
- Acridine-orange localization and reversible pH perturbation
- limitations
- This study localizes acidification; it does not identify a particular modern proton-pump subunit or measure whole-body calcium flux.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Gallus gallus
- plain_language
- Bone-resorbing cells create a locally acidic space against bone.
- primary_references
- [baron1985] Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border (1985). https://rupress.org/jcb/article/101/6/2210/21648/Cell-mediated-extracellular-acidification-and-bone DOI: 10.1083/jcb.101.6.2210
- tissue_or_cell_type
- Osteoclast-bone interface
Calcium: mechanism-first literature curation (2026-09-17) · lines 1081–1091
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Acridine-orange localization and reversible pH perturbation · source_derived_draft · unverified_draft
### osteoclast-lacuna-acidification Resorbing osteoclasts acidified the extracellular compartment beneath their ruffled border and reacidified it after ammonium chloride washout. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Bone-resorbing cells create a locally acidic space against bone. organism: Gallus gallus tissue_or_cell_type: Osteoclast-bone interface experimental_model: Acridine-orange localization and reversible pH perturbation limitations: This study localizes acidification; it does not identify a particular modern proton-pump subunit or measure whole-body calcium flux. compartment_description: Sealed extracellular resorption lacuna [baron1985] Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border (1985). https://rupress.org/jcb/article/101/6/2210/21648/Cell-mediated-extracellular-acidification-and-bone DOI: 10.1083/jcb.101.6.2210
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.