Component
Acetaldehyde-derived DNA adducts in oral mucosa
Acetaldehyde-derived DNA adducts in oral mucosa. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Levels of the acetaldehyde-derived DNA adduct N2-ethyl-deoxyguanosine were increased in oral mucosa DNA from rhesus monkeys exposed to alcohol.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/27056945.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c01bbdf333ac3266271f33f59dc90b58fb733575ade7193b1e9c1664983ac4f5", "start_char": 0, "end_char": 2034, "text_sha256": "c01bbdf333ac3266271f33f59dc90b58fb733575ade7193b1e9c1664983ac4f5"}
- experimental_model
- Rhesus monkeys exposed to alcohol with oral mucosa DNA adduct measurement
- exposure
- Alcohol exposure with mass-spectrometric adduct quantification
- limitations
- A primate measurement of the specific adduct. It establishes exposure of the tissue DNA, not that a tumour follows.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Rhesus monkey
- plain_language
- The first breakdown product sticks to DNA in the tissue that alcohol touches first.
- primary_references
- [alcohol-p27056945] Increased levels of the acetaldehyde-derived DNA adduct N 2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol. (2016). https://pubmed.ncbi.nlm.nih.gov/27056945/ DOI: 10.1093/mutage/gew016
- tissue_or_cell_type
- Oral mucosa
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 527–538
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rhesus monkeys exposed to alcohol with oral mucosa DNA adduct measurement · source_derived_draft · unverified_draft
### alcohol-dna-adducts Levels of the acetaldehyde-derived DNA adduct N2-ethyl-deoxyguanosine were increased in oral mucosa DNA from rhesus monkeys exposed to alcohol. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The first breakdown product sticks to DNA in the tissue that alcohol touches first. organism: Rhesus monkey tissue_or_cell_type: Oral mucosa experimental_model: Rhesus monkeys exposed to alcohol with oral mucosa DNA adduct measurement limitations: A primate measurement of the specific adduct. It establishes exposure of the tissue DNA, not that a tumour follows. exposure: Alcohol exposure with mass-spectrometric adduct quantification evidence_span: {"source_cache": "artifacts/alcohol-research/27056945.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c01bbdf333ac3266271f33f59dc90b58fb733575ade7193b1e9c1664983ac4f5", "start_char": 0, "end_char": 2034, "text_sha256": "c01bbdf333ac3266271f33f59dc90b58fb733575ade7193b1e9c1664983ac4f5"} [alcohol-p27056945] Increased levels of the acetaldehyde-derived DNA adduct N 2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol. (2016). https://pubmed.ncbi.nlm.nih.gov/27056945/ DOI: 10.1093/mutage/gew016
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.