Component
C-peptide response during an oral glucose tolerance test
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Insulin and C-peptide areas were 42% and 39% greater with caffeine, while blood glucose was similar among trials.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test.
- limitations
- Small acute experiment. Beta blockade supports an adrenergic contribution, not proof that it is the only mechanism or that a blocker should be used to counter caffeine.
- nutrient_topic
- Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
- plain_language
- More insulin was measured without a corresponding glucose difference.
- primary_references
- Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12015346/ · DOI 10.1152/japplphysiol.01229.2001
Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 492–498
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test. · source_derived_draft · unverified_draft
## caf-insulin More insulin was measured without a corresponding glucose difference. Insulin and C-peptide areas were 42% and 39% greater with caffeine, while blood glucose was similar among trials. Model: Seven healthy men; 5 mg/kg caffeine, 80 mg propranolol, combination or placebo before an oral glucose tolerance test. Limitations: Small acute experiment. Beta blockade supports an adrenergic contribution, not proof that it is the only mechanism or that a blocker should be used to counter caffeine. Evidence access: Primary abstract Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12015346/ · DOI 10.1152/japplphysiol.01229.2001
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.