Component
Number of myonuclei per muscle fibre
Number of myonuclei per muscle fibre. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Strength and muscle mass increased more with active recovery than with cold water immersion, with isokinetic work up 19%, type II fibre cross-sectional area up 17% and myonuclei per fibre up 26% in the active recovery group but not the immersion group.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/26174323.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "91eff53ecc4779637af3d6fd47a67892729e3a896fdc8738f69d1c7936b4787d", "start_char": 0, "end_char": 1595, "text_sha256": "91eff53ecc4779637af3d6fd47a67892729e3a896fdc8738f69d1c7936b4787d"}
- experimental_model
- Twelve weeks of strength training in 21 men with immersion or active recovery, plus a biopsy study in nine men
- exposure
- 10 minutes of cold water immersion after each training session, twice weekly for 12 weeks
- limitations
- A randomised training study with muscle biopsies. It measures long-term adaptation rather than acute recovery, which is why it can disagree with the soreness literature without contradicting it.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Human
- plain_language
- Twelve weeks of plunging after lifting left people smaller and weaker than not plunging.
- primary_references
- [cold-p26174323] Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. (2015). https://pubmed.ncbi.nlm.nih.gov/26174323/ DOI: 10.1113/jp270570
- tissue_or_cell_type
- Skeletal muscle
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 806–817
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve weeks of strength training in 21 men with immersion or active recovery, plus a biopsy study in nine men · source_derived_draft · unverified_draft
### cold-cwi-blunts-hypertrophy Strength and muscle mass increased more with active recovery than with cold water immersion, with isokinetic work up 19%, type II fibre cross-sectional area up 17% and myonuclei per fibre up 26% in the active recovery group but not the immersion group. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Twelve weeks of plunging after lifting left people smaller and weaker than not plunging. organism: Human tissue_or_cell_type: Skeletal muscle experimental_model: Twelve weeks of strength training in 21 men with immersion or active recovery, plus a biopsy study in nine men limitations: A randomised training study with muscle biopsies. It measures long-term adaptation rather than acute recovery, which is why it can disagree with the soreness literature without contradicting it. exposure: 10 minutes of cold water immersion after each training session, twice weekly for 12 weeks evidence_span: {"source_cache": "artifacts/cold-research/26174323.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "91eff53ecc4779637af3d6fd47a67892729e3a896fdc8738f69d1c7936b4787d", "start_char": 0, "end_char": 1595, "text_sha256": "91eff53ecc4779637af3d6fd47a67892729e3a896fdc8738f69d1c7936b4787d"} [cold-p26174323] Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. (2015). https://pubmed.ncbi.nlm.nih.gov/26174323/ DOI: 10.1113/jp270570
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.