Component
Inhibitory phosphorylation of skeletal-muscle PDH
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Muscle PDK4 expression increased 13-fold, alongside greater inhibitory PDH phosphorylation.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Thirteen adults; seven-day fast, muscle biopsies and exercise testing.
- limitations
- Co-occurrence supports the pathway interpretation but does not isolate causality.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- Muscle reduced access from carbohydrate into oxidation.
- primary_references
- Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39747857/ · DOI 10.1038/s41467-024-55418-0
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 176–182
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Thirteen adults; seven-day fast, muscle biopsies and exercise testing. · source_derived_draft · unverified_draft
## fast-pdk4 Muscle reduced access from carbohydrate into oxidation. Muscle PDK4 expression increased 13-fold, alongside greater inhibitory PDH phosphorylation. Model: Thirteen adults; seven-day fast, muscle biopsies and exercise testing. Limitations: Co-occurrence supports the pathway interpretation but does not isolate causality. Evidence access: Primary abstract Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39747857/ · DOI 10.1038/s41467-024-55418-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.