Component
Mouse multidrug and toxin extrusion protein 1 / Mate1
Mouse multidrug and toxin extrusion protein 1 / Mate1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Renal clearance and renal secretory clearance of metformin in Mate1(-/-) mice were approximately 18% and 14% of those in wild-type mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/metformin-research/19332510.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "79d5ec9a2d5c447e349d0e00742a2f2a05a3c9f9581199c4dde1f9b7910c029c", "start_char": 0, "end_char": 1536, "text_sha256": "79d5ec9a2d5c447e349d0e00742a2f2a05a3c9f9581199c4dde1f9b7910c029c"}
- experimental_model
- Targeted disruption of the murine Mate1 gene with metformin pharmacokinetics
- exposure
- Single intravenous metformin 5 mg/kg in Mate1(-/-) and Mate1(+/+) mice
- limitations
- Mouse pharmacokinetics; it does not establish a human exposure threshold or a clinical toxicity risk.
- nutrient_topic
- Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. · Metformin
- organism
- Mouse
- plain_language
- Removing the exit pump left most of the drug in the body.
- primary_references
- [metformin-p19332510] Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. (2009). https://pubmed.ncbi.nlm.nih.gov/19332510/ DOI: 10.1124/mol.109.056242
- tissue_or_cell_type
- Kidney and liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Metformin: transport, molecular targets, gut mechanisms and nutrient interactions (2026-09-19) · lines 268–279
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted disruption of the murine Mate1 gene with metformin pharmacokinetics · source_derived_draft · unverified_draft
### metformin-mate1-null-clearance Renal clearance and renal secretory clearance of metformin in Mate1(-/-) mice were approximately 18% and 14% of those in wild-type mice. Condition category: machinery_impairment nutrient_topic: Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. plain_language: Removing the exit pump left most of the drug in the body. organism: Mouse tissue_or_cell_type: Kidney and liver experimental_model: Targeted disruption of the murine Mate1 gene with metformin pharmacokinetics limitations: Mouse pharmacokinetics; it does not establish a human exposure threshold or a clinical toxicity risk. exposure: Single intravenous metformin 5 mg/kg in Mate1(-/-) and Mate1(+/+) mice evidence_span: {"source_cache": "artifacts/metformin-research/19332510.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "79d5ec9a2d5c447e349d0e00742a2f2a05a3c9f9581199c4dde1f9b7910c029c", "start_char": 0, "end_char": 1536, "text_sha256": "79d5ec9a2d5c447e349d0e00742a2f2a05a3c9f9581199c4dde1f9b7910c029c"} [metformin-p19332510] Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. (2009). https://pubmed.ncbi.nlm.nih.gov/19332510/ DOI: 10.1124/mol.109.056242
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.