Component
Mouse AMPK catalytic subunit alpha 2 / Prkaa2
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Combined AMPK-alpha1/alpha2 siRNA depletion in C2C12 cells abolished the mitochondrial-biogenesis response to astaxanthin.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text, RNA interference methods and Figure 7
- experimental_model
- Mouse C2C12 cells; AMPK-alpha1/2 siRNA, astaxanthin 50 micromolar.
- limitations
- Dual-subunit depletion cannot identify one subunit as sufficient; culture exposure is not an oral dose.
- nutrient_topic
- Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Astaxanthin
- plain_language
- The mitochondrial response depended on intact energy-sensing machinery.
- primary_references
- Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32003547/ · DOI 10.1002/jcsm.12530
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19) · lines 334–340
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse C2C12 cells; AMPK-alpha1/2 siRNA, astaxanthin 50 micromolar. · source_derived_draft · unverified_draft
## astaxanthin-ampk-loss The mitochondrial response depended on intact energy-sensing machinery. Combined AMPK-alpha1/alpha2 siRNA depletion in C2C12 cells abolished the mitochondrial-biogenesis response to astaxanthin. Model: Mouse C2C12 cells; AMPK-alpha1/2 siRNA, astaxanthin 50 micromolar. Limitations: Dual-subunit depletion cannot identify one subunit as sufficient; culture exposure is not an oral dose. Evidence access: Primary full text, RNA interference methods and Figure 7 Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32003547/ · DOI 10.1002/jcsm.12530
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.