Component
Methanandamide, a stable anandamide analogue
Methanandamide, a stable anandamide analogue. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
THC and methanandamide had differential effects in CB1 knockout and wild-type mice, with the effects of THC dependent on the receptor while some effects of the anandamide analogue were not.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/14718593.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "422efbafe3e999138f4591acf2a7e5126919ba85d84637aeb320927062c5b2a8", "start_char": 0, "end_char": 1836, "text_sha256": "422efbafe3e999138f4591acf2a7e5126919ba85d84637aeb320927062c5b2a8"}
- experimental_model
- THC and methanandamide compared in CB1 knockout and wild-type mice
- exposure
- THC and a stable anandamide analogue across genotypes
- limitations
- The comparison of two agonists across the same genotypes is what shows the receptor accounts for the drug but not for everything cannabinoid-like.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- Take the receptor away and the drug stops working, though not every cannabinoid-like effect disappears with it.
- primary_references
- [thc-p14718593] Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice. (2004). https://pubmed.ncbi.nlm.nih.gov/14718593/ DOI: 10.1124/jpet.103.055376
- tissue_or_cell_type
- Whole body
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 426–437
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · THC and methanandamide compared in CB1 knockout and wild-type mice · source_derived_draft · unverified_draft
### thc-thc-requires-cb1 THC and methanandamide had differential effects in CB1 knockout and wild-type mice, with the effects of THC dependent on the receptor while some effects of the anandamide analogue were not. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Take the receptor away and the drug stops working, though not every cannabinoid-like effect disappears with it. organism: Mouse tissue_or_cell_type: Whole body experimental_model: THC and methanandamide compared in CB1 knockout and wild-type mice limitations: The comparison of two agonists across the same genotypes is what shows the receptor accounts for the drug but not for everything cannabinoid-like. exposure: THC and a stable anandamide analogue across genotypes evidence_span: {"source_cache": "artifacts/thc-research/14718593.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "422efbafe3e999138f4591acf2a7e5126919ba85d84637aeb320927062c5b2a8", "start_char": 0, "end_char": 1836, "text_sha256": "422efbafe3e999138f4591acf2a7e5126919ba85d84637aeb320927062c5b2a8"} [thc-p14718593] Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice. (2004). https://pubmed.ncbi.nlm.nih.gov/14718593/ DOI: 10.1124/jpet.103.055376
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.