Component
Transport by the mesenteric lymphatic route
Transport by the mesenteric lymphatic route. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Tritiated dihydrocapsaicin was mainly absorbed via the portal system and not by a mesenteric lymphangial one, and the radioactivity in portal blood was composed of 85% dihydrocapsaicin and 15% of its metabolite 8-methyl nonanoic acid bound to the albumin fraction, with dihydrocapsaicin-hydrolysing enzyme activity found in jejunal tissue, indicating a partial first-pass effect during absorption.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/6710495.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b", "start_char": 0, "end_char": 1416, "text_sha256": "a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b"}
- experimental_model
- In vivo and in situ gastrointestinal absorption studies in rats with tritiated dihydrocapsaicin
- exposure
- Capsaicin and dihydrocapsaicin administered into stomach, jejunum and ileum, with 2,4-dinitrophenol and sodium cyanide as metabolic inhibitors
- limitations
- Establishes both the route and the first metabolite by direct measurement in portal blood. A 1984 rat study using tritium label rather than mass spectrometry.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- The gut wall snips the molecule in two, and one of the pieces is a small fatty acid that travels on in the blood.
- primary_references
- [dhc-p6710495] Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. (1984). https://pubmed.ncbi.nlm.nih.gov/6710495/ DOI: 10.1016/0041-008x(84)90121-2
- tissue_or_cell_type
- Stomach, jejunum, ileum and portal blood
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · In vivo and in situ gastrointestinal absorption studies in rats with tritiated dihydrocapsaicin · source_derived_draft · unverified_draft
### dhc-releases-8-mna Tritiated dihydrocapsaicin was mainly absorbed via the portal system and not by a mesenteric lymphangial one, and the radioactivity in portal blood was composed of 85% dihydrocapsaicin and 15% of its metabolite 8-methyl nonanoic acid bound to the albumin fraction, with dihydrocapsaicin-hydrolysing enzyme activity found in jejunal tissue, indicating a partial first-pass effect during absorption. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The gut wall snips the molecule in two, and one of the pieces is a small fatty acid that travels on in the blood. organism: Rat tissue_or_cell_type: Stomach, jejunum, ileum and portal blood experimental_model: In vivo and in situ gastrointestinal absorption studies in rats with tritiated dihydrocapsaicin limitations: Establishes both the route and the first metabolite by direct measurement in portal blood. A 1984 rat study using tritium label rather than mass spectrometry. exposure: Capsaicin and dihydrocapsaicin administered into stomach, jejunum and ileum, with 2,4-dinitrophenol and sodium cyanide as metabolic inhibitors evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/6710495.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b", "start_char": 0, "end_char": 1416, "text_sha256": "a0a9a5cb2178f2b266fffe5efbd9580a0a1b5c03dd86b4bfe92b105194eb1f9b"} [dhc-p6710495] Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. (1984). https://pubmed.ncbi.nlm.nih.gov/6710495/ DOI: 10.1016/0041-008x(84)90121-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.