Component
LOX Ser280Arg variant
Independent protein state record; interpretation is limited by each linked claim and its study context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Expressed LOX Ser280Arg and Ser348Arg variants had lower catalytic activity than wild-type LOX.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Human-family genetic study with expressed mutant-enzyme assays.
- limitations
- Variant-specific activity measurements; free lysine was not shown to rescue the defect.
- organism
- Human
- plain_language
- Some inherited enzyme changes reduce activity despite the presence of lysine substrates.
- primary_references
- [lox-variants-2016] LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections (2016). https://pubmed.ncbi.nlm.nih.gov/26838787/ DOI: 10.1161/CIRCRESAHA.115.307130
- tissue_or_cell_type
- Not specified as a whole tissue; see experimental model.
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 517–525
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human-family genetic study with expressed mutant-enzyme assays. · source_derived_draft · unverified_draft
### lox-variants-enzyme-activity Expressed LOX Ser280Arg and Ser348Arg variants had lower catalytic activity than wild-type LOX. Plain language: Some inherited enzyme changes reduce activity despite the presence of lysine substrates. Condition category: machinery_impairment organism: Human tissue_or_cell_type: Not specified as a whole tissue; see experimental model. experimental_model: Human-family genetic study with expressed mutant-enzyme assays. limitations: Variant-specific activity measurements; free lysine was not shown to rescue the defect. [lox-variants-2016] LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections (2016). https://pubmed.ncbi.nlm.nih.gov/26838787/ DOI: 10.1161/CIRCRESAHA.115.307130
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.