Component
Loss of the righting reflex
Loss of the righting reflex. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The GABA-A receptor and hypnotic potencies of etomidate and the etomidate analogs ranged by 91-fold and 53-fold respectively, these potency measurements were significantly correlated with r = 0.72, but neither measurement correlated with drug hydrophobicity with r = 0.019 and 0.005 respectively, statistically significant and predictive comparative molecular field analysis models were generated, and a pharmacophore model was built revealing both the structural elements associated with high potency and the interactions that these elements make with the etomidate-binding site.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/26691905.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1143ce4efd922ff301b6a1ca54f0a84b8ffe08bf53946b8fcee1f3ad17a8b7eb", "start_char": 0, "end_char": 1844, "text_sha256": "1143ce4efd922ff301b6a1ca54f0a84b8ffe08bf53946b8fcee1f3ad17a8b7eb"}
- experimental_model
- Voltage clamp electrophysiology of a sensitising channel mutant with a loss of righting reflex assay and comparative molecular field analysis
- exposure
- A series of etomidate analogs spanning a 91-fold range of receptor potency
- limitations
- Recombinant receptors carrying a mutation that enhances anaesthetic sensitivity, paired with an animal endpoint. The correlation is across analogs rather than within one drug.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Rat and recombinant receptor
- plain_language
- How well these anaesthetics work tracks their exact shape at a binding site and not at all how greasy they are.
- primary_references
- [gb-p26691905] γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs. (2016). https://pubmed.ncbi.nlm.nih.gov/26691905/ DOI: 10.1097/aln.0000000000000992
- tissue_or_cell_type
- Recombinant alpha1beta3gamma2 receptors and whole animals
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Voltage clamp electrophysiology of a sensitising channel mutant with a loss of righting reflex assay and comparative molecular field analysis · source_derived_draft · unverified_draft
### gb-potency-is-structural-not-greasy The GABA-A receptor and hypnotic potencies of etomidate and the etomidate analogs ranged by 91-fold and 53-fold respectively, these potency measurements were significantly correlated with r = 0.72, but neither measurement correlated with drug hydrophobicity with r = 0.019 and 0.005 respectively, statistically significant and predictive comparative molecular field analysis models were generated, and a pharmacophore model was built revealing both the structural elements associated with high potency and the interactions that these elements make with the etomidate-binding site. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: How well these anaesthetics work tracks their exact shape at a binding site and not at all how greasy they are. organism: Rat and recombinant receptor tissue_or_cell_type: Recombinant alpha1beta3gamma2 receptors and whole animals experimental_model: Voltage clamp electrophysiology of a sensitising channel mutant with a loss of righting reflex assay and comparative molecular field analysis limitations: Recombinant receptors carrying a mutation that enhances anaesthetic sensitivity, paired with an animal endpoint. The correlation is across analogs rather than within one drug. exposure: A series of etomidate analogs spanning a 91-fold range of receptor potency evidence_span: {"source_cache": "artifacts/gaba-research/26691905.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1143ce4efd922ff301b6a1ca54f0a84b8ffe08bf53946b8fcee1f3ad17a8b7eb", "start_char": 0, "end_char": 1844, "text_sha256": "1143ce4efd922ff301b6a1ca54f0a84b8ffe08bf53946b8fcee1f3ad17a8b7eb"} [gb-p26691905] γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs. (2016). https://pubmed.ncbi.nlm.nih.gov/26691905/ DOI: 10.1097/aln.0000000000000992
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.