Component
Intestinal flavin-coenzyme hydrolysis
Brush-border hydrolysis releasing free riboflavin from dietary flavin coenzymes.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Rat brush-border preparations released free riboflavin from FAD; inhibiting coenzyme hydrolysis reduced its competition with tracer riboflavin uptake.
Experimental context and source evidence
- evidence_location
- Abstract; intestinal fractionation and EDTA competition experiments
- experimental_model
- Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings
- exposure
- Flavin coenzymes with or without EDTA during tracer uptake.
- limitations
- Rat ex vivo evidence; molecular identities of the hydrolases were not established.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Rattus norvegicus
- plain_language
- Dietary FAD can supply absorbable riboflavin after intestinal cleavage.
- primary_references
- [transport-diet-1982] FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: role in intestinal absorption of dietary riboflavin. (1982). https://doi.org/10.1093/jn/112.2.263 DOI: 10.1093/jn/112.2.263
- tissue_or_cell_type
- Small-intestinal mucosa
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 124–135
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings · source_derived_draft · unverified_draft
### transport-dietary-fad-hydrolysis Rat brush-border preparations released free riboflavin from FAD; inhibiting coenzyme hydrolysis reduced its competition with tracer riboflavin uptake. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Dietary FAD can supply absorbable riboflavin after intestinal cleavage. organism: Rattus norvegicus tissue_or_cell_type: Small-intestinal mucosa experimental_model: Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings limitations: Rat ex vivo evidence; molecular identities of the hydrolases were not established. exposure: Flavin coenzymes with or without EDTA during tracer uptake. evidence_location: Abstract; intestinal fractionation and EDTA competition experiments [transport-diet-1982] FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: role in intestinal absorption of dietary riboflavin. (1982). https://doi.org/10.1093/jn/112.2.263 DOI: 10.1093/jn/112.2.263
Complete structured claim and evidenceRat brush-border preparations released free riboflavin from FMN; inhibiting coenzyme hydrolysis reduced its competition with tracer riboflavin uptake.
Experimental context and source evidence
- evidence_location
- Abstract; intestinal fractionation and EDTA competition experiments
- experimental_model
- Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings
- exposure
- Flavin coenzymes with or without EDTA during tracer uptake.
- limitations
- Rat ex vivo evidence; molecular identities of the hydrolases were not established.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Rattus norvegicus
- plain_language
- Dietary FMN can supply absorbable riboflavin after intestinal cleavage.
- primary_references
- [transport-diet-1982] FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: role in intestinal absorption of dietary riboflavin. (1982). https://doi.org/10.1093/jn/112.2.263 DOI: 10.1093/jn/112.2.263
- tissue_or_cell_type
- Small-intestinal mucosa
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 111–122
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings · source_derived_draft · unverified_draft
### transport-dietary-fmn-hydrolysis Rat brush-border preparations released free riboflavin from FMN; inhibiting coenzyme hydrolysis reduced its competition with tracer riboflavin uptake. Condition category: normal nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Dietary FMN can supply absorbable riboflavin after intestinal cleavage. organism: Rattus norvegicus tissue_or_cell_type: Small-intestinal mucosa experimental_model: Rat mucosal fractionation, hydrolase assays and radiolabeled-riboflavin uptake in everted intestinal rings limitations: Rat ex vivo evidence; molecular identities of the hydrolases were not established. exposure: Flavin coenzymes with or without EDTA during tracer uptake. evidence_location: Abstract; intestinal fractionation and EDTA competition experiments [transport-diet-1982] FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: role in intestinal absorption of dietary riboflavin. (1982). https://doi.org/10.1093/jn/112.2.263 DOI: 10.1093/jn/112.2.263
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.