Component
Insulin receptor substrate 1, Akt and p70 S6 kinase phosphorylation
Insulin receptor substrate 1, Akt and p70 S6 kinase phosphorylation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Intracellular salicylate concentrations increased within five minutes in both rat fast-twitch and slow-twitch muscle, threonine-172 phosphorylation of the AMP-activated protein kinase alpha subunit increased dose- and time-dependently with increases in both alpha-1 and alpha-2 activity, and these were accompanied by increased 3-O-methyl-D-glucose transport and decreases in ATP, phosphocreatine and glycogen, while phosphorylation of insulin receptor substrate 1, Akt and p70 S6 kinase was unchanged.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/aspirin-research/25256746.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8cd347665e1de7dc2cadee06da087e2526d4fc11aefef6f7ce15cb33f6234c2", "start_char": 0, "end_char": 1171, "text_sha256": "e8cd347665e1de7dc2cadee06da087e2526d4fc11aefef6f7ce15cb33f6234c2"}
- experimental_model
- Incubation of rat fast-twitch epitrochlearis and slow-twitch soleus muscle with salicylate
- exposure
- Salicylate applied to isolated muscle with glucose transport and nucleotide measurements
- limitations
- Adds the tissue and the energy measurements. Isolated muscle at concentrations set by the incubation buffer, which is not a plasma concentration.
- nutrient_topic
- Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. · Aspirin / acetylsalicylic acid
- organism
- Rat
- plain_language
- Muscle takes up more glucose without any help from insulin, and its energy stores fall while it happens.
- primary_references
- [asa-p25256746] Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles. (2014). https://pubmed.ncbi.nlm.nih.gov/25256746/ DOI: 10.1016/j.bbrc.2014.09.066
- tissue_or_cell_type
- Skeletal muscle
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Incubation of rat fast-twitch epitrochlearis and slow-twitch soleus muscle with salicylate · source_derived_draft · unverified_draft
### asa-muscle-glucose-uptake Intracellular salicylate concentrations increased within five minutes in both rat fast-twitch and slow-twitch muscle, threonine-172 phosphorylation of the AMP-activated protein kinase alpha subunit increased dose- and time-dependently with increases in both alpha-1 and alpha-2 activity, and these were accompanied by increased 3-O-methyl-D-glucose transport and decreases in ATP, phosphocreatine and glycogen, while phosphorylation of insulin receptor substrate 1, Akt and p70 S6 kinase was unchanged. Condition category: biomarker_context nutrient_topic: Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. plain_language: Muscle takes up more glucose without any help from insulin, and its energy stores fall while it happens. organism: Rat tissue_or_cell_type: Skeletal muscle experimental_model: Incubation of rat fast-twitch epitrochlearis and slow-twitch soleus muscle with salicylate limitations: Adds the tissue and the energy measurements. Isolated muscle at concentrations set by the incubation buffer, which is not a plasma concentration. exposure: Salicylate applied to isolated muscle with glucose transport and nucleotide measurements evidence_span: {"source_cache": "artifacts/aspirin-research/25256746.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8cd347665e1de7dc2cadee06da087e2526d4fc11aefef6f7ce15cb33f6234c2", "start_char": 0, "end_char": 1171, "text_sha256": "e8cd347665e1de7dc2cadee06da087e2526d4fc11aefef6f7ce15cb33f6234c2"} [asa-p25256746] Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles. (2014). https://pubmed.ncbi.nlm.nih.gov/25256746/ DOI: 10.1016/j.bbrc.2014.09.066
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.