Component
Interleukin 15
Interleukin 15; cytokine exposure or readout, not a nutrient.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
RA with IL-15 promoted dendritic-cell IL-12p70 release.
Experimental context and source evidence
- evidence_locator
- Abstract and Figure 3
- experimental_model
- Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models.
- exposure
- RA plus IL-15
- limitations
- No claim that dietary vitamin A causes coeliac disease.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- An inflammatory cytokine can redirect RA-associated immune signaling.
- primary_references
- [va-depaolo-2011] Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens (2011). https://www.nature.com/articles/nature09849 DOI: 10.1038/nature09849
- tissue_or_cell_type
- Dendritic cells
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1292–1303
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models. · source_derived_draft · unverified_draft
### va-sig-ra-il15-il12 RA with IL-15 promoted dendritic-cell IL-12p70 release. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: An inflammatory cytokine can redirect RA-associated immune signaling. organism: Mus musculus tissue_or_cell_type: Dendritic cells experimental_model: Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models. limitations: No claim that dietary vitamin A causes coeliac disease. evidence_locator: Abstract and Figure 3 exposure: RA plus IL-15 [va-depaolo-2011] Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens (2011). https://www.nature.com/articles/nature09849 DOI: 10.1038/nature09849
Complete structured claim and evidenceRA with IL-15 promoted dendritic-cell IL-23 release.
Experimental context and source evidence
- evidence_locator
- Abstract and Figure 3
- experimental_model
- Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models.
- exposure
- RA plus IL-15
- limitations
- Different context from isolated naive T-cell induction.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- RA participates in a proinflammatory response in this cytokine setting.
- primary_references
- [va-depaolo-2011] Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens (2011). https://www.nature.com/articles/nature09849 DOI: 10.1038/nature09849
- tissue_or_cell_type
- Dendritic cells
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1305–1316
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models. · source_derived_draft · unverified_draft
### va-sig-ra-il15-il23 RA with IL-15 promoted dendritic-cell IL-23 release. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: RA participates in a proinflammatory response in this cytokine setting. organism: Mus musculus tissue_or_cell_type: Dendritic cells experimental_model: Mouse dendritic-cell/T-cell experiments and IL-15-rich intestinal models. limitations: Different context from isolated naive T-cell induction. evidence_locator: Abstract and Figure 3 exposure: RA plus IL-15 [va-depaolo-2011] Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens (2011). https://www.nature.com/articles/nature09849 DOI: 10.1038/nature09849
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.