Component
Hypoalgesia / reduced pain sensitivity
Hypoalgesia / reduced pain sensitivity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Cannabinoid CB1 receptor knockout mice showed increased mortality, hypoactivity and hypoalgesia.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/10318961.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee2674f143f23f9030564139676e845091ab75adaa02b8ab0220bc77860e38ef", "start_char": 0, "end_char": 1144, "text_sha256": "ee2674f143f23f9030564139676e845091ab75adaa02b8ab0220bc77860e38ef"}
- experimental_model
- CB1 receptor knockout mice characterised for survival, activity and nociception
- exposure
- Constitutive CB1 deletion
- limitations
- Shows what removing the receptor costs the animal at baseline, independently of any drug. The increased mortality is a colony observation.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- Animals without the receptor are worse off before any drug is given.
- primary_references
- [thc-p10318961] Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. (1999). https://pubmed.ncbi.nlm.nih.gov/10318961/ DOI: 10.1073/pnas.96.10.5780
- tissue_or_cell_type
- Whole body
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 413–424
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CB1 receptor knockout mice characterised for survival, activity and nociception · source_derived_draft · unverified_draft
### thc-cb1-null-phenotype Cannabinoid CB1 receptor knockout mice showed increased mortality, hypoactivity and hypoalgesia. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Animals without the receptor are worse off before any drug is given. organism: Mouse tissue_or_cell_type: Whole body experimental_model: CB1 receptor knockout mice characterised for survival, activity and nociception limitations: Shows what removing the receptor costs the animal at baseline, independently of any drug. The increased mortality is a colony observation. exposure: Constitutive CB1 deletion evidence_span: {"source_cache": "artifacts/thc-research/10318961.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee2674f143f23f9030564139676e845091ab75adaa02b8ab0220bc77860e38ef", "start_char": 0, "end_char": 1144, "text_sha256": "ee2674f143f23f9030564139676e845091ab75adaa02b8ab0220bc77860e38ef"} [thc-p10318961] Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. (1999). https://pubmed.ncbi.nlm.nih.gov/10318961/ DOI: 10.1073/pnas.96.10.5780
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.