Component
Human FAS-associated death domain protein / FADD
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Indicaxanthin prevented smoke-extract-triggered Fas aggregation and recruitment of FADD and caspase-8 at erythrocyte membranes.
Experimental context and source evidence
- dose
- Indicaxanthin 1-5 micromolar; aqueous cigarette smoke extract
- duration
- 3 h
- evidence_access
- Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.
- evidence_scope
- literature_reviewed; source-derived curation, not universally established human effects
- experimental_model
- Human isolated red blood cells challenged with cigarette smoke extract
- limitations
- An isolated-cell smoke-extract experiment does not establish protection against smoking-related disease; no direct Fas-binding assay was reported in the abstract.
- nutrient_topic
- Betalains collection; each molecular form, species, exposure and preparation remains explicit. · Betalains
- organism
- Human isolated red blood cells challenged with cigarette smoke extract
- plain_language
- Indicaxanthin prevented smoke-extract-triggered Fas aggregation and recruitment of FADD and caspase-8 at erythrocyte membranes.
- primary_references
- Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling. (2024). https://pubmed.ncbi.nlm.nih.gov/38520710/ DOI: 10.1002/biof.2051
- route
- Ex vivo co-incubation
- tissue
- Erythrocyte membrane and cytosol
Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 457–465
Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Human isolated red blood cells challenged with cigarette smoke extract · source_derived_draft · unverified_draft
## betalains-redcell-disc Indicaxanthin prevented smoke-extract-triggered Fas aggregation and recruitment of FADD and caspase-8 at erythrocyte membranes. Model/species: Human isolated red blood cells challenged with cigarette smoke extract Tissue: Erythrocyte membrane and cytosol Exposure: Indicaxanthin 1-5 micromolar; aqueous cigarette smoke extract Route: Ex vivo co-incubation Duration: 3 h Limits: An isolated-cell smoke-extract experiment does not establish protection against smoking-related disease; no direct Fas-binding assay was reported in the abstract. Primary reference: Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas-mediated signaling. (2024). https://pubmed.ncbi.nlm.nih.gov/38520710/ DOI: 10.1002/biof.2051
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.