Component
GABA-A receptor alpha-4 subunit / GABRA4
GABA-A receptor alpha-4 subunit / GABRA4. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
A naturally occurring GABA-A receptor subunit partnership was identified with high sensitivity to ethanol.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/17159992.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fbee66c99566521e71ae6b95b34c77426888dd791b27b2e3dad3a215a12441f7", "start_char": 0, "end_char": 1048, "text_sha256": "fbee66c99566521e71ae6b95b34c77426888dd791b27b2e3dad3a215a12441f7"}
- experimental_model
- Recombinant GABA-A receptor subunit combinations tested for ethanol sensitivity
- exposure
- Ethanol at low millimolar concentrations on defined subunit partnerships
- limitations
- Identifies a subunit combination sensitive at drinking-relevant concentrations, which had been the main objection to GABA-A as a direct target.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Recombinant human and rodent subunits
- plain_language
- A specific combination of receptor parts responds to alcohol at the concentrations drinking produces.
- primary_references
- [alcohol-p17159992] A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. (2007). https://pubmed.ncbi.nlm.nih.gov/17159992/ DOI: 10.1038/nn1813
- tissue_or_cell_type
- Extrasynaptic GABA-A receptors
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 319–330
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant GABA-A receptor subunit combinations tested for ethanol sensitivity · source_derived_draft · unverified_draft
### alcohol-gaba-subunit-sensitivity A naturally occurring GABA-A receptor subunit partnership was identified with high sensitivity to ethanol. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: A specific combination of receptor parts responds to alcohol at the concentrations drinking produces. organism: Recombinant human and rodent subunits tissue_or_cell_type: Extrasynaptic GABA-A receptors experimental_model: Recombinant GABA-A receptor subunit combinations tested for ethanol sensitivity limitations: Identifies a subunit combination sensitive at drinking-relevant concentrations, which had been the main objection to GABA-A as a direct target. exposure: Ethanol at low millimolar concentrations on defined subunit partnerships evidence_span: {"source_cache": "artifacts/alcohol-research/17159992.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fbee66c99566521e71ae6b95b34c77426888dd791b27b2e3dad3a215a12441f7", "start_char": 0, "end_char": 1048, "text_sha256": "fbee66c99566521e71ae6b95b34c77426888dd791b27b2e3dad3a215a12441f7"} [alcohol-p17159992] A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. (2007). https://pubmed.ncbi.nlm.nih.gov/17159992/ DOI: 10.1038/nn1813
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.