Component
Lactylation of hydroxyl groups by intestinal fungi
Lactylation of hydroxyl groups by intestinal fungi. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains yielded eight metabolites including seven previously undescribed ones, with the main reactions revealed to be hydroxylation, alcohol oxidation and lactylation, the lactylation of hydroxyl groups being mediated mainly by Rhizopus oryzae.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/36578383.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338", "start_char": 0, "end_char": 1090, "text_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338"}
- experimental_model
- Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination
- exposure
- Dihydrocapsaicin incubated with cultivated human intestinal fungal strains
- limitations
- An in vitro biotransformation study with cultivated strains, not a gut community. The enzyme-inhibition result is a property of an isolated metabolite, not a demonstrated effect in an animal.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Human intestinal fungi
- plain_language
- Fungi living in the human gut rework the molecule into eight different products, most of them new to science.
- primary_references
- [dhc-p36578383] Biotransformation of dihydrocapsaicin by human intestinal fungi and the inhibitory effects of metabolites against LSD1. (2022). https://pubmed.ncbi.nlm.nih.gov/36578383/ DOI: 10.1016/j.heliyon.2022.e12325
- tissue_or_cell_type
- In vitro culture
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination · source_derived_draft · unverified_draft
### dhc-fungal-biotransformation Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains yielded eight metabolites including seven previously undescribed ones, with the main reactions revealed to be hydroxylation, alcohol oxidation and lactylation, the lactylation of hydroxyl groups being mediated mainly by Rhizopus oryzae. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Fungi living in the human gut rework the molecule into eight different products, most of them new to science. organism: Human intestinal fungi tissue_or_cell_type: In vitro culture experimental_model: Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination limitations: An in vitro biotransformation study with cultivated strains, not a gut community. The enzyme-inhibition result is a property of an isolated metabolite, not a demonstrated effect in an animal. exposure: Dihydrocapsaicin incubated with cultivated human intestinal fungal strains evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/36578383.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338", "start_char": 0, "end_char": 1090, "text_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338"} [dhc-p36578383] Biotransformation of dihydrocapsaicin by human intestinal fungi and the inhibitory effects of metabolites against LSD1. (2022). https://pubmed.ncbi.nlm.nih.gov/36578383/ DOI: 10.1016/j.heliyon.2022.e12325
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.