Component
Fulvestrant / ICI 182780
Fulvestrant / ICI 182780. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
DIM at 10 micromolar increased proliferation in estrogen-deprived breast-cancer cells; an ERalpha antagonist blocked the response.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/25048790.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3729748e0cd55782230ad119eddfb3a79e0cdfd78503f5dbf397ae0ab5f68a17", "start_char": 0, "end_char": 1824, "text_sha256": "3729748e0cd55782230ad119eddfb3a79e0cdfd78503f5dbf397ae0ab5f68a17"}
- experimental_model
- Gene expression, chromatin, inhibitors and growth assays
- exposure
- DIM 10 versus 50 micromolar; estradiol absent
- limitations
- The authors call 10 micromolar obtainable, but this is not a demonstrated human tissue concentration or clinical tumor outcome. Estrogen context and concentration matter.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- Human MCF-7 and T47D cells
- plain_language
- A growth-promoting response appeared under one defined hormonal condition.
- primary_references
- [dim-p25048790] Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. (2014). https://pubmed.ncbi.nlm.nih.gov/25048790/ DOI: 10.1186/1471-2407-14-524
- tissue_or_cell_type
- ERalpha and proliferation
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 610–621
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Gene expression, chromatin, inhibitors and growth assays · source_derived_draft · unverified_draft
### dim-eralpha-proliferation DIM at 10 micromolar increased proliferation in estrogen-deprived breast-cancer cells; an ERalpha antagonist blocked the response. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A growth-promoting response appeared under one defined hormonal condition. organism: Human MCF-7 and T47D cells tissue_or_cell_type: ERalpha and proliferation experimental_model: Gene expression, chromatin, inhibitors and growth assays limitations: The authors call 10 micromolar obtainable, but this is not a demonstrated human tissue concentration or clinical tumor outcome. Estrogen context and concentration matter. exposure: DIM 10 versus 50 micromolar; estradiol absent evidence_span: {"source_cache": "artifacts/dim-research/25048790.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3729748e0cd55782230ad119eddfb3a79e0cdfd78503f5dbf397ae0ab5f68a17", "start_char": 0, "end_char": 1824, "text_sha256": "3729748e0cd55782230ad119eddfb3a79e0cdfd78503f5dbf397ae0ab5f68a17"} [dim-p25048790] Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. (2014). https://pubmed.ncbi.nlm.nih.gov/25048790/ DOI: 10.1186/1471-2407-14-524
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.