Component
Drosophila Pink1
Drosophila Pink1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Vitamin K2 transferred electrons in Drosophila mitochondria and improved ATP production; Heix-mutant defects were rescued by K2.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/22582012.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1f7c8600fd883b912c1fd697b1bffb6e442e2763230347e5c198d88c0c6bb4cc", "start_char": 0, "end_char": 926, "text_sha256": "1f7c8600fd883b912c1fd697b1bffb6e442e2763230347e5c198d88c0c6bb4cc"}
- experimental_model
- Genetic modifier and mitochondrial function experiments
- exposure
- Heix/Pink1 defects and vitamin K2 rescue
- limitations
- Fly electron-transfer rescue does not establish replacement of human CoQ10 or treatment of Parkinson disease.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Drosophila
- plain_language
- An energy role was found in flies and is recorded with that species boundary.
- primary_references
- [k2-p22582012] Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. (2012). https://pubmed.ncbi.nlm.nih.gov/22582012/ DOI: 10.1126/science.1218632
- tissue_or_cell_type
- Mitochondria
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 864–875
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genetic modifier and mitochondrial function experiments · source_derived_draft · unverified_draft
### k2-fly-mitochondria Vitamin K2 transferred electrons in Drosophila mitochondria and improved ATP production; Heix-mutant defects were rescued by K2. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: An energy role was found in flies and is recorded with that species boundary. organism: Drosophila tissue_or_cell_type: Mitochondria experimental_model: Genetic modifier and mitochondrial function experiments limitations: Fly electron-transfer rescue does not establish replacement of human CoQ10 or treatment of Parkinson disease. exposure: Heix/Pink1 defects and vitamin K2 rescue evidence_span: {"source_cache": "artifacts/k2-research/22582012.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1f7c8600fd883b912c1fd697b1bffb6e442e2763230347e5c198d88c0c6bb4cc", "start_char": 0, "end_char": 926, "text_sha256": "1f7c8600fd883b912c1fd697b1bffb6e442e2763230347e5c198d88c0c6bb4cc"} [k2-p22582012] Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. (2012). https://pubmed.ncbi.nlm.nih.gov/22582012/ DOI: 10.1126/science.1218632
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.