Component
Fenoprofen
Fenoprofen. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In rat isolated adipocytes and hepatocytes incubated with tritiated glycerol there was a high-affinity enzymatic process for synthesis of triacylglycerol containing fenoprofen which was stereospecific for the R enantiomer, with apparent Km values of 1.0 micromolar in adipocytes and 2.8 micromolar in hepatocytes, consistent with stereospecific formation of R-2-arylpropionyl-CoA thioesters at clinically relevant unbound concentrations; a second low-affinity process in hepatocytes occurred at concentrations far above those found in man at usual doses.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ibuprofen-research/3377800.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "facf726355f08978d9f447e3cfbd803611011abed9f95b46970540d246ea11e6", "start_char": 0, "end_char": 962, "text_sha256": "facf726355f08978d9f447e3cfbd803611011abed9f95b46970540d246ea11e6"}
- experimental_model
- Rat isolated adipocytes and hepatocytes incubated with tritiated glycerol and single enantiomers of fenoprofen
- exposure
- R or S fenoprofen at concentrations spanning the clinically relevant unbound range
- limitations
- Tested with fenoprofen rather than ibuprofen, which is recorded on the claim. It shows where the activated R thioester can end up when it is not epimerised.
- nutrient_topic
- Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. · Ibuprofen
- organism
- Rat
- plain_language
- The activated R form can be built into body fat as a fake fatty acid, at concentrations people actually reach.
- primary_references
- [ibu-p3377800] The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols. (1988). https://pubmed.ncbi.nlm.nih.gov/3377800/ DOI: 10.1016/0006-2952(88)90537-0
- tissue_or_cell_type
- Adipocytes and hepatocytes
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat isolated adipocytes and hepatocytes incubated with tritiated glycerol and single enantiomers of fenoprofen · source_derived_draft · unverified_draft
### ibu-r-enantiomer-enters-body-fat In rat isolated adipocytes and hepatocytes incubated with tritiated glycerol there was a high-affinity enzymatic process for synthesis of triacylglycerol containing fenoprofen which was stereospecific for the R enantiomer, with apparent Km values of 1.0 micromolar in adipocytes and 2.8 micromolar in hepatocytes, consistent with stereospecific formation of R-2-arylpropionyl-CoA thioesters at clinically relevant unbound concentrations; a second low-affinity process in hepatocytes occurred at concentrations far above those found in man at usual doses. Condition category: normal nutrient_topic: Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. plain_language: The activated R form can be built into body fat as a fake fatty acid, at concentrations people actually reach. organism: Rat tissue_or_cell_type: Adipocytes and hepatocytes experimental_model: Rat isolated adipocytes and hepatocytes incubated with tritiated glycerol and single enantiomers of fenoprofen limitations: Tested with fenoprofen rather than ibuprofen, which is recorded on the claim. It shows where the activated R thioester can end up when it is not epimerised. exposure: R or S fenoprofen at concentrations spanning the clinically relevant unbound range evidence_span: {"source_cache": "artifacts/ibuprofen-research/3377800.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "facf726355f08978d9f447e3cfbd803611011abed9f95b46970540d246ea11e6", "start_char": 0, "end_char": 962, "text_sha256": "facf726355f08978d9f447e3cfbd803611011abed9f95b46970540d246ea11e6"} [ibu-p3377800] The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols. (1988). https://pubmed.ncbi.nlm.nih.gov/3377800/ DOI: 10.1016/0006-2952(88)90537-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.