Component
Erythrocyte pyridoxamine phosphate oxidase activation coefficient
Measured process or biological entity; consult each linked claim for the experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Erythrocyte PPO activity and its activation coefficient responded to B2 supplementation and correlated with EGRAC; enzyme activity showed a dose response.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- A B6-activation enzyme provides a B2-sensitive functional assay.
- experimental_model
- Assay-development study using hemolysates from the RIBOFEM riboflavin intervention; same trial registration ISRCTN35811298.
- exposure
- Erythrocyte PPO activity with/without flavin activation; 2 and 4 mg/day supplementation arms. Not independent replication of RIBOFEM.
- limitations
- Assay-development analysis shares samples with RIBOFEM; not independent replication. Proposed utility in G6PD deficiency requires population-specific validation.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Homo sapiens
- plain_language
- An enzyme used to activate B6 can also reveal aspects of B2 status because it needs an FMN cofactor.
- primary_references
- [b2-mushtaq2009] Erythrocyte pyridoxamine phosphate oxidase activity: a potential biomarker of riboflavin status? (2009). https://pubmed.ncbi.nlm.nih.gov/19740970/ DOI: 10.3945/ajcn.2009.28338
- tissue_or_cell_type
- Human clinical setting
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1653–1664
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Assay-development study using hemolysates from the RIBOFEM riboflavin intervention; same trial registration ISRCTN35811298. · source_derived_draft · unverified_draft
### b2-ppo-biomarker-response Erythrocyte PPO activity and its activation coefficient responded to B2 supplementation and correlated with EGRAC; enzyme activity showed a dose response. Condition category: biomarker_context nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: An enzyme used to activate B6 can also reveal aspects of B2 status because it needs an FMN cofactor. organism: Homo sapiens tissue_or_cell_type: Human clinical setting experimental_model: Assay-development study using hemolysates from the RIBOFEM riboflavin intervention; same trial registration ISRCTN35811298. limitations: Assay-development analysis shares samples with RIBOFEM; not independent replication. Proposed utility in G6PD deficiency requires population-specific validation. exposure: Erythrocyte PPO activity with/without flavin activation; 2 and 4 mg/day supplementation arms. Not independent replication of RIBOFEM. cross_nutrient: A B6-activation enzyme provides a B2-sensitive functional assay. [b2-mushtaq2009] Erythrocyte pyridoxamine phosphate oxidase activity: a potential biomarker of riboflavin status? (2009). https://pubmed.ncbi.nlm.nih.gov/19740970/ DOI: 10.3945/ajcn.2009.28338
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.