Component
Plasma elimination half-life
Plasma elimination half-life. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In man absorption from the gastrointestinal tract was essentially complete with time to maximum concentration at approximately one hour or less, bioavailability was attenuated by pre-systemic hepatic metabolism in all species, the elimination half-life in man was 3.7 hours, the majority of radioactivity was excreted in faeces with no unchanged drug detected in human excreta, five principal metabolic pathways operated in all species including piperazine N-demethylation, and following oral doses the areas under the curve for the piperazine N-desmethyl and N,N-desethyl metabolites were 55 and 27% that of the parent compound.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/sildenafil-research/10219969.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a54758a045a866a0807663e835df338d7b9d650790d7202426425ce056eb58", "start_char": 0, "end_char": 1621, "text_sha256": "e8a54758a045a866a0807663e835df338d7b9d650790d7202426425ce056eb58"}
- experimental_model
- Pharmacokinetics after single intravenous and oral doses of labelled and unlabelled drug across five species
- exposure
- Carbon-14 labelled sildenafil with excretion balance and metabolite profiling
- limitations
- Cross-species pharmacokinetics with a mass balance. Single doses.
- nutrient_topic
- Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. · Sildenafil
- organism
- Mouse, rat, rabbit, dog and human
- plain_language
- It is absorbed completely, cut down by the liver on the way through, and the main breakdown product reaches about half the parent exposure.
- primary_references
- [sil-p10219969] Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. (1999). https://pubmed.ncbi.nlm.nih.gov/10219969/ DOI: 10.1080/004982599238687
- tissue_or_cell_type
- Whole body
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pharmacokinetics after single intravenous and oral doses of labelled and unlabelled drug across five species · source_derived_draft · unverified_draft
### sil-handling-and-metabolites In man absorption from the gastrointestinal tract was essentially complete with time to maximum concentration at approximately one hour or less, bioavailability was attenuated by pre-systemic hepatic metabolism in all species, the elimination half-life in man was 3.7 hours, the majority of radioactivity was excreted in faeces with no unchanged drug detected in human excreta, five principal metabolic pathways operated in all species including piperazine N-demethylation, and following oral doses the areas under the curve for the piperazine N-desmethyl and N,N-desethyl metabolites were 55 and 27% that of the parent compound. Condition category: normal nutrient_topic: Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. plain_language: It is absorbed completely, cut down by the liver on the way through, and the main breakdown product reaches about half the parent exposure. organism: Mouse, rat, rabbit, dog and human tissue_or_cell_type: Whole body experimental_model: Pharmacokinetics after single intravenous and oral doses of labelled and unlabelled drug across five species limitations: Cross-species pharmacokinetics with a mass balance. Single doses. exposure: Carbon-14 labelled sildenafil with excretion balance and metabolite profiling evidence_span: {"source_cache": "artifacts/sildenafil-research/10219969.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a54758a045a866a0807663e835df338d7b9d650790d7202426425ce056eb58", "start_char": 0, "end_char": 1621, "text_sha256": "e8a54758a045a866a0807663e835df338d7b9d650790d7202426425ce056eb58"} [sil-p10219969] Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. (1999). https://pubmed.ncbi.nlm.nih.gov/10219969/ DOI: 10.1080/004982599238687
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.